The aim of this study is to evaluate whether symptom recurrence, after successful FODMAP elimination, is dose-dependent in patients with IBS. The effect of a blinded reintroduction of FODMAP powders fructans and mannitol will be investigated in a crossover dose-escalation scheme for the identification of the eliciting dose in individual patients. The reintroduction of FODMAPs is performed after a successful elimination by the LFD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
45
The FODMAP powders will be reintroduced in three different doses, each for three consecutive days.
AZ Sint Lucas
Bruges, Belgium
Dose dependency
The study aims to determine the daily dose level of mannitol or fructans that induces symptom recurrence in IBS.
Time frame: 18 months
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