Role of the exposome on allergy, caries, and neurophysiological development in childhood.
Role of the exposome and epigenetics on allergy, caries, and neurophysiological development in childhood as studied in a birth cohort of 650 trioses. The exposome includes repeated measures of nutrition, micronutritients, microbiota, toxic agents and the clinical outcomes, diagnoses of allergy, caries and neurophysiological functions/dysfunctions.
Study Type
OBSERVATIONAL
Enrollment
1,950
No intervention
Sunderby Hospital
Luleå, Norrbotten County, Sweden
Number of participants with excema
Excema
Time frame: Outcome at one year
Number of participants with food allergy
Food allergy
Time frame: Outcome at one year
Number of participants with frhino-conjuctivitis
Rhino-conjunctivitis
Time frame: Outcome at one year
Number of participants with asthma
Asthma
Time frame: Outcome at one year
Number of participants with excema
Excema
Time frame: Outcome at four years
Number of participants with food allergy
Food allergy
Time frame: Outcome at four years
Number of participants with rhino-conjunctivitis
Rhino-conjuctivitis
Time frame: Outcome at four years
Number of participants with asthma
Asthma
Time frame: Outcome at four years
Number of participants with excema
Excema
Time frame: Outcome at six years
Number of participants with food allergy
Food allergy
Time frame: Outcome at six years
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Number of participants with rhino-conjunctivitis
Rhino-conjunctivitis
Time frame: Outcome at six years
Number of participants with asthma
Asthma
Time frame: Outcome at six years
Numbers of caries lesions (DeMFS = decayed, enamel included, missed, filled, tooth surfaces, in each child
Cariesfree individuals have a DeMFS = 0 and increasing scores means increasing degree of caries. Maximum DeMFS = 148, minumum DeMFS = 0.
Time frame: Outcome at four years
Child cognition as measured by Wechsler Preschool and Primary Scale of Intelligence
Cognitive development will be tested face-to-face with Wechsler Preschool and Primary Scale of Intelligence. Increasing scores means increasing intelligence.
Time frame: Outcome at four years