This study investigates the effects of Splenda, an artificial sweetener powder containing sucralose, on post-prandial blood glucose levels, appetite scores and subsequent energy intake.
Participants are randomly assigned to receive either the placebo drink (4.5g maltodextrin dissolved in 250ml water) or the Splenda drink (4.5g Splenda dissolved in 250ml water) taken alongside a high calorie breakfast. Blood glucose measurements will be obtained through finger-pricking and appetite will be measured using self-reported visual analogue scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast. Energy intake will be measured using a 24 hour food diary.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
51
4.5g Splenda containing 1% sucralose, 95% maltodextrin, dissolved in 250ml water and consumed with a high carbohydrate breakfast.
4.5g maltodextrin dissolved in 250ml water and consumed with a high carbohydrate breakfast.
Meal consisting of 30g cereal with 100ml skimmed milk, 1.5 slices white toast with 12g margarine, providing 386kcal, 61.4g carbohydrate, 10.4g protein and 10.1g fat.
King's College London
London, United Kingdom
Change in blood glucose
Capillary blood glucose from fingerprick and measured using glucose monitor
Time frame: -5 to 180 minutes (measured from baseline up to 90min every 15min and from 90-180min every 30min)
Change in appetite
Feelings of hunger, desire to eat, fullness and alertness measured using Visual Analogue Scale (VAS)
Time frame: -5 to 180 minutes (measured from baseline up to 90min every 15min and from 90-180min every 30min)
24 hour energy intake
Food intake over the 24 hours of the study day using a 24 hour food diary entered into dietary analysis software
Time frame: 0 - 24 hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.