The aim of the project is to assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e. growth retardation, premature birth, and congenital developmental defects) and maternal morbidity (gestational hypertension, diabetes and preeclampsia) in a prospective population-wide register study.
Study Type
OBSERVATIONAL
Enrollment
256,659
Assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e. growth retardation, premature birth, and congenital developmental defects) and maternal morbidity (gestational hypertension, diabetes and preeclampsia) in a prospective population-wide register based cohort.
Birth outcome - birthweight
grams as measured at birth
Time frame: at birth
Birth outcome - Small for gestational age (SGA)
\<-2 standard deviations (SD) from the average weight at the gestational age and sex at partus (Marsal et al. 1996. Acta Paediatr 85(7): 843-848)
Time frame: at birth
Birth outcome - Large for gestational age (LGA)
\>2 standard deviations (SD) from the average weight at the gestational age and sex at partus (Marsal et al. 1996. Acta Paediatr 85(7): 843-848)
Time frame: at birth
Birth outcome - major congenital malformations
ICD10- codes: Q00-Q99 within the first 28 days postpartum, categorized as major congenital malformations according to European Surveillance of Congenital Anomalies (EUROCAT 2014)
Time frame: at birth
Maternal health - Gestational hypertension/preeclampsia
ICD10-codes: O13-O14. Diagnosis at maternal or primary care
Time frame: during gestation
Maternal health - Gestational diabetes mellus
ICD10-codes: O24 (excluding pregestational diabetes). Diagnosis at maternal or primary care
Time frame: during gestation
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