RL Versus Glucose Saline in Cancer Patient Undergoing Major Surgeries and Its Impact on Electrolytes, GLC & pH

National Cancer Institute, Egypt60 enrolled

Overview

To compare two electrolytes maintenance in perioperative period in children undergoing major surgeries on perioperative change in pH,lactate,sodium and glucose level

Patients were randomized into 2 groups ringer lactate versus 5%dextrose in 0.9% saline,using a computer generated random list in blocks of 4 after recruitment the enrolling investigators opened sealed opaque envelopes that concealed group allocation participants ,trial investigators,attending anesthetist providing general anesthesia for the cases and the outcomes were blinded to group allocation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Fluid and Electrolyte Imbalance

Interventions

Lactated ringer and dextrose 5%OTHER

Fluid use perioperative

Eligibility

Sex: ALLMin age: 1 YearMax age: 10 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 1to 10 years Children undergoing major surgeries ie considered major if any invasive procedure in which extensive resection will be preformed e.g body cavity is opened,organs are removed and normal anatomy is altered abd duration not less than 2 hours or more than 5 hours. Exclusion Criteria: * patient guardian refusal \_ Children with documented endocrine distrubances(DM,inborn error of metabolism,hyperthyroidism) * age less than one year * preexisting renal disease,hepatic disease and patien suffering from heart failure. * preexisting electrolyte imbalance (normal sodium level 135-145)

Locations (1)

National Cancer institute

Cairo, Egypt

Outcomes

Primary Outcomes

PH and lactate level

Three ABG will be collected from the patient. The first at start before any intervention,the second after start of replacement and the third at the end of the operation.

Time frame: In the introperative period

Secondary Outcomes

Sodium and glucose level

Three ABGs will be collected.The first at the start of the operation before any surgical intervention,the second after the start of fluid replacement and the last sample at the end of the operation.

Time frame: The intraoperative period

Data from ClinicalTrials.gov

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