Histamine Dihydrochloride and Interleukin-2 in Primary Resectable Pancreatic Cancer

Inclusion Criteria: 1. Subjects must give written informed consent prior to initiation of therapy, in keeping with the policies of the institution. 2. Subject is a male or female age \>18 3. By the surgeon´s evaluation fit for pancreatic surgery 4. Subjects must have radiologic, and or cytologic confirmation of primary pancreatic cancer Exclusion Criteria (any of the following): 1. Class III or IV cardiac disease, hypotension or severe hypertension, vasomotor instability, serious or uncontrolled cardiac dysrhythmias (including ventricular arrhythmias) at any time, acute myocardial infarction within the past 6 months, active uncontrolled angina pectoris or symptomatic arteriosclerotic peripheral blood vessel disease. 2. History of uncontrolled seizures, severe central nervous system disorders, or psychiatric disability thought to be clinically significant in the opinion of the Investigator and adversely affecting compliance to protocol. 3. Any other condition or symptoms preventing the patient from entering the study, according to the PI's judgement. 4. A woman of childbearing potential (WOCBP) must agree to comply with using an effective contraceptive method for the duration of the treatment (a WOCBP is a sexually mature woman who is not surgically sterile or has not been naturally postmenopausal for at least 12 consecutive months). Investigators shall counsel WOCBP and male subjects who are sexually active with WOCBP on the importance of pregnancy prevention and the implications of an unexpected pregnancy. Investigators shall advise WOCBP and male subjects who are sexually active with WOCBP on the use of highly effective methods of contraception. Highly effective methods of contraception have a failure rate of \< 1% when used consistently and correctly. Local laws and regulations may require use of alternative and/or additional contraception methods. One of the highly effective methods of contraception listed below is required during study duration and until the end of relevant systemic exposure, defined as 5 months after the end of study treatment.