Application of Different Modes of Esketamine Administration in Pediatric Day Circumcision

Yangzhou University70 enrolled

Overview

To explore the application of different administration modes of esketamine in pediatric day circumcision, in order to find an anesthesia scheme more suitable for day pediatric circumcision.

The current clinical study believes that esketamine is suitable for pediatric anesthesia because of its advantages of light respiratory depression, low secretions, low incidence of psychomotor reactions and fast recovery of anesthesia, but there are few related studies on its administration mode and timing in clinical application, this study aims to explore the application of different administration methods of esketamine in pediatric day circumcision, and find an anesthesia scheme more suitable for day circumcision, in order to provide new ideas for anesthesia for pediatric day circumcision.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Pain

Interventions

Esketamine of single injectionDRUG

Single group: give esketamine 0.75 mg/kg at the time of induction

Esketamine of Intermittent injectionDRUG

Intermittent group: give esketamine 0.5mg/kg during anesthesia induction, and during the measuring ring esketamine 0.25mg/kg was given again

Eligibility

Sex: MALEMin age: 6 YearsMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologists (ASA) class I and II children * Age 5-12 years * Foreskin cerclage is proposed * No history of upper respiratory tract infection in the past two weeks * Obtain the consent of the child's family Exclusion Criteria: * Hepatic and renal insufficiency, coagulation dysfunction * Those who are allergic to esketamine * History of cognitive impairment * epilepsy * other psychiatric and neurological disorders

Outcomes

Primary Outcomes

One-time success rate of anesthesia

No movement during anesthesia

Time frame: During surgery

Secondary Outcomes

Systolic blood pressure

Time frame: During surgery

Diastolic blood pressure

Time frame: During surgery

Heart rate

Time frame: During surgery

intraoperative propofol dosage, esketamine dosage

Time frame: During surgery

Duration of surgery

Time frame: During surgery

Time to open eyes

Time frame: During surgery

Time to talk

Time frame: During surgery

VAS(visual analogue scale) score

A score to assess pain, use a swimming ruler about 10 cm long, marked with 10 scales on one side, with "0" and "10" ends at each end, 0 points means no pain, and 10 points represent the most severe pain that is unbearable.

Time frame: 12 hours after the end of surgery

Data from ClinicalTrials.gov

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