OTX-DED for the Short-term Treatment of the Symptoms of Dry Eye Disease (DED)

Inclusion Criteria: * VAS eye dryness severity score ≥ 35 and ≤ 90 at screening. * Investigator assessment of bulbar conjunctival hyperemia grade ≥ 2 (CCLRU; 0 - 4 scale). * Unanesthetized Schirmer of \> 0 and ≤ 10 mm. * Must not have used Artificial Tears during the Screening period. * IOP in both eyes ≥ 5 mmHg and ≤21 mmHg. Exclusion Criteria: * Have worn contact lenses in the 4 weeks prior to the screening visit and/or are unwilling to discontinue use of contact lenses throughout the study period. * Have a history of glaucoma or ocular hypertension or have a history of intraocular pressure (IOP) \< 5 mmHg or \> 24 mmHg.