[18F]AlF-NOTA-pentixather PET/CT in Patients With Suspected Primary Hyperaldosteronism

Inclusion Criteria: * Persistent hypertension or refractory hypertension (blood pressure \>140/90 mmHg with a combination of three antihypertensive drugs, including diuretics) with hypokalemia of blood pressure \>160/100 mmHg. * Uncontrollable hypokalemia with or without hypertension. Persistent hypertension or refractory hypertension with blood pressure \>160/100 mmHg and aldosterone-renin ratio (ARR) ≥30 (ng/dl)/(ng/ml/h). * Positive captopril test (≤30% decrease in plasma aldosterone level after captopril administration) is a sufficient but not mandatory condition. * Patients with CT showing unilateral or bilateral adrenal nodules with well-defined borders but normal serum potassium and ARR \<30 (ng/dl)/(ng/ml/h) were also included in the study. Exclusion Criteria: * Female patients who are pregnant (or intend to become pregnant within six months), breastfeeding, or unwilling to use contraception. * Abnormal cardiopulmonary function or mental status, unable to tolerate prone for 20 minutes. * Refusal to sign an informed consent form or inability or unwillingness to comply with the investigator-approved study protocol. * Other conditions deemed by the investigator to be inappropriate for participation in this study.