The primary aim of this project is to test if OCOsense glasses can function as a digital phenotyping tool derived from behavioural and physiological signals related to facial expression and motion recorded using the glasses.
Assessment of participants living with a DSM5 research diagnosis of Bipolar disorder or Major depressive disorder as well as healthy controls who will be recruited and characterised through precision phenotyping involving cross-sectional assessment of biobehavioural and physiological markers of the symptoms of depression. Correlations between objective (i.e., OCOsense glasses captured) and subjective (i.e., self-reported) symptoms of depression will be measured within as well as across diagnoses. The resulting biobehavioral clusters will form the building block of a digital phenotyping tool based upon the wider spectrum of non-verbal behaviours and physiology defined and affected by the phenotype of depression.
Study Type
OBSERVATIONAL
Enrollment
84
Volunteers wear OCOsense glasses continuously during testing to monitor biobehavioural responses to tasks
Emteq Labs
Brighton, East Sussex, United Kingdom
The demonstration of a significant association between facial expression-derived objective valence and self-reported subjective mood under controlled exposure
Measures of facial muscular activation in the corrugator supercilli and zygomaticus major muscles. By comparing the ratio of corrugator to zygomatic muscle activation, the OCOsense glasses will produce: \- Objective valence at a given time (ratio/intensity of corrugator to zygomatic muscle activation at that time).
Time frame: 4 hours
The demonstration of a significant association between facial expression derived objective mood and self-reported subjective mood under controlled exposure
Measures of facial muscular activation in the corrugator supercilli and zygomaticus major muscles. By measuring corrugator and zygomatic muscle activation, the OCOsense glasses will produce: \- Objective mood during negatively valenced exposures, neutrally valenced exposures and positively valenced exposures described in terms of expression intensity and variability for each exposure.
Time frame: 4 hours
Identifying physical activity engagement.
The OCOsense glasses contain Inertial Measurement Units (IMU) sensors. By detecting inertial displacement over time OCOsense will detect: \- Movement: a measure of movement over a period of time - specifically, how much of the time period is spent (i) stationary, (ii) in motion, (iii) fidgeting, (iv) engaging with a variety of activities of daily living
Time frame: 2 hours
Investigating the relationship between vocal prosody and self-reported subjective mood
The OCOsense glasses contain a microphone. By detecting vocal parameters over time OCOsense will detect: \- the nonsemantic lexical features of speech related to pitch and tone whilst participants verbally recall a positive event in their life or engage with a semi-structured diagnostic interview.
Time frame: 2 hours
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