To evaluate the efficacy of the weekly use of corifollitropin alfa in double ovarian stimulation process and to compare it to the conventional protocol with daily medication administration.
The purpose of this pilot study is to evaluate the efficacy of the weekly use of corifollitropin alfa in terms of ovarian stimulation results and its biological outcomes (total number of oocytes retrieved) in case of ovarian stimulation cycles in double stimulation modality (DUOSTIM) and in comparison with the conventional DUOSTIM protocol: daily administration of gonadotropins.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Instituto Bernabeu
Alicante, Spain
Total Number of Retrieved Oocytes
To investigate the total number of oocytes retrieved through ovarian stimulation in double ovarian stimulation cycles (DUOSTIM) utilizing weekly subcutaneous injections of Corifollitropin alfa (study group) vs. daily injections of gonadotropins (control group).
Time frame: Through study completion, an average of four weeks
Number of MII Oocytes
To compare the total number of MII oocytes obtained in double stimulation cycles in study vs control groups
Time frame: Through study completion, an average of four months
Duration of Ovarian Stimulation
Total days of follicular and luteal phases
Time frame: Through study completion, an average of four months
Number of Injections
Number of injections during the DUOSTIM cycle
Time frame: Through study completion, an average of four months
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Variable dose.