A Study of SKB264 (MK-2870; Sac-TMT) for the Treatment of Participants With Advanced or Metastatic Non-small Cell Lung Cancer (SKB264-II-04) (MK-2870-003)

Inclusion Criteria 1. Subjects must be at least 18 years of age on day of signing informed consent, regardless of gender; 2. Subjects with histologically or cytologically confirmed locally advanced or metastatic NSCLC ; 3. Subjects for NSCLC should be confirmed to be EGFR (Epidermal growth factor receptor) wild-type and ALK (Anaplastic lymphoma kinase) fusion gene negative; or confirmed to harbor EGFR mutation; 4. Locally advanced or metastatic NSCLC subjects without actionable EGFR mutations and ALK fusion genes, no prior systemic treatment; subjects with EGFR mutation, no prior systemic treatment or failed prior EGFR-TKI (Tyrosine kinase inhibitor) treatment; 5. Subjects are able to provide tumor blocks or slides before the first dose of study intervention; 6. Subject must have at least one radiographically measurable lesion as per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 criteria; 7. Subject has an Eastern Cooperative Oncology Group (ECOG) performance status of either 0 or 1; 8. Life expectancy at least 3 months for the subject; 9. Adequate organ function; 10. Subjects must have recovered from all toxicities led by prior treatment; 11. Contraceptive methods used by male and female subjects must comply with contraceptive methods of local regulations for clinical study subjects; 12. Subjects should voluntarily participate in the study, sign the ICF, and will be able to comply with the protocol-specified visits and relevant procedures. Exclusion Criteria 1. Subjects with mixed SCLC histopathological features; 2. Subjects with a known history of prior malignancy; 3. Subjects with known meningeal metastases, brainstem metastases, spinal cord metastases and/or compression, or active central nervous system (CNS) metastases; 4. Subjects with ≥ Grade 2 peripheral neuropathy; 5. Subjects who had arteriovenous thromboembolic events, tumor invasion/encasement of vital organs/vessels, risk of esophageal-tracheal/pleural fistula, or current superior vena cava syndrome; 6. Subjects with active inflammatory bowel disease or previous clear history of inflammatory bowel disease; 7. Subjects who suffer from cardiovascular diseases of clinical significance; 8. Subjects with a history of interstitial lung disease (ILD)/non-infectious pneumonitis that required steroids; 9. Subjects with uncontrolled systemic disease as judged by the Investigator; 10. Subjects with active autoimmune disease that required systemic treatment in the past 2 years; 11. Subjects with active hepatitis B or hepatitis C; 12. Subjects with known history of Human Immunodeficiency Virus (HIV) 13. Subjects with known active tuberculosis; 14. Subjects with known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation; 15. Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the study; 16. Subjects whose condition deteriorated rapidly, such as severe changes in performance status, during the screening process prior to the first dose of study intervention; 17. Subjects with other circumstances that, in the opinion of the Investigator, are not appropriate for participation in this study.