This is multicentric, spontaneous, observational, retrospective and prospective study.
In the retrospective part of the study, Tissue Microarrays (TMA) will be prepared from surgical samples of breast tissue from a series of patients with TNBC type breast cancer. In the prospective part of the study will be evaluated the expression of some selenoproteins by ELISA in plasma samples obtained from up to 100 healthy subjects and about 300 (\~100 per year) patients with basally metastatic TNBC breast cancer (150) and metastatic (150) before any treatment.
Study Type
OBSERVATIONAL
Enrollment
300
Istituto Nazionale Tumori - Fondazione "G.Pascale", IRCCS
Napoli, Napoli, Italy
RECRUITINGIstituto Nazionale Tumori Regina Elena
Roma, Roma, Italy
RECRUITINGUse of immunohistochemistry investigation (IHC)
In the retrospective part of the study, Tissue Microarrays (TMA) will be prepared from surgical samples of breast tissue from a series of patients with TNBC type breast cancer. The expression of some of the twenty-five selenoproteins will be evaluated by immunohistochemical investigation (IHC) on the TMA (Tumor Microarrays).
Time frame: 3 years
Prospective evaluation of expression of some selenoproteins by kit ELISA in plasma samples
In the prospective part of the study will be evaluated the expression of some selenoproteins by ELISA in plasma samples obtained from up to 100 healthy subjects and about 300 (\~100 per year) patients with basally metastatic TNBC breast cancer (150) and metastatic (150) before any treatment.
Time frame: 3 years
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