Monovalent Chimpanzee Adenoviral-Vectored Marburg Virus Vaccine in Healthy Adults

Inclusion Criteria: 1. Able and willing to complete and provide written informed consent prior to any study procedure; including injection site photograph consent, completing an Assessment of Understanding (AoU) prior to enrollment by answering 9 out of 10 questions correctly at least once in 3 attempts, and including optional consent for retention of blood samples for potential future testing and assay development. Note: Participants can be enrolled even if they do not provide optional consent for retention of blood samples for potential future testing and assay development. 2. Able to read and write the language used in diary card. 3. Male or non-pregnant female 18 to 70 years of age (inclusive) at time of informed consent. 4. Is capable of understanding and agrees to comply with planned study procedures and to be available for all clinic follow-up for all planned study visits. 5. Able to provide proof of identity to the satisfaction of the study clinician completing the enrollment process. 6. Has a means to be contacted and to contact the investigator during the study. 7. Agree not to receive any vaccine within 28 days from study vaccination (prior and after), with the exception of an emergency use authorization or authorized non-adenoviral vectored coronavirus disease 2019 (COVID-19) vaccine, which may be given within 14 days of study vaccination. 8. Agree not to donate bone marrow, blood, or blood products until 3 months after the study vaccination. 9. In good general health without clinically significant medical conditions, based on medical history, physical examination, vital signs, and clinical laboratory results as deemed acceptable by the principal investigator. 10. Clinical laboratory results within 28 days prior to vaccination within the site's laboratory reference ranges (or deemed not clinically significant by the principal investigator) for the following parameters: hematology (complete blood count (CBC) including hemoglobin, white blood cell (WBC), red blood cell (RBC), total lymphocyte count); coagulation tests (prothrombin time, international normalized ratio (INR), fibrinogen); chemistry (C-reactive protein, d-dimer, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum creatinine). A laboratory result that is outside the reference range and is deemed not clinically significant by the principal investigator will not exclude the participant. 11. Has a body mass index (BMI) \>17 and ≤37 at screening. Female participant specific criteria: 12. Negative pregnancy serum test at screening, and negative urine pregnancy test before vaccination, if of reproductive potential. 13. Agrees to use an effective means of birth control from at least 21 days prior to enrollment through 24 weeks after study vaccination if assessed to be woman of childbearing potential UNLESS they fulfill one of the following criteria: * At least 1 year postmenopausal. * Surgically sterile. Male participants must agree: 14. Not to father a child or donate sperm through study end. 15. To use a barrier (condom) means of birth control from vaccination through study end, if assessed to be of reproductive potential. Exclusion Criteria: 1. Pregnant or lactating female or plans to become pregnant or breastfeed starting from study vaccination through to study end. 2. Has any medical disease or condition that, in the opinion of the investigator, precludes study participation. This includes any acute, subacute, intermittent, or chronic medical disease or condition that * would place the participant at an unacceptable risk of injury, * render the participant unable to comply with the requirements of the protocol, * or may interfere with the evaluation of responses or the participant's successful completion of the trial; (chronic conditions that are well-controlled and medically stable, ie, no change in treatment for medical reasons occurred in the last 6 months, are allowed at the discretion of the principal investigator, eg, hypertension, asthma, thyroid disease). The medical disease or condition also includes any confirmed or suspected immunosuppressive or immunodeficient condition resulting from disease (eg, malignancy, HIV infection) or immunosuppressive/cytotoxic therapy (eg, medications used during cancer chemotherapy, organ transplantation or to treat autoimmune disorders). 3. Serology screen positive for infectious diseases (hepatitis B, hepatitis C, HIV 1 and 2, syphilis). 4. Known prior exposure to MARV or prior diagnosis of Marburg virus disease (MVD). 5. Current diagnosis of COVID-19 by reverse transcription polymerase chain reaction (RT-PCR) or antigenic testing or current signs and symptoms of COVID-19. Participants may be enrolled 14 days post resolution of all signs and symptoms of COVID-19 or of testing positive for COVID-19 in asymptomatic participants. 6. History of or active status of any of the following clinically significant conditions: * Serious adverse reactions to vaccines such as anaphylaxis, urticaria (hives), respiratory difficulty, angioedema, or abdominal pain. * Allergic reaction to excipients in the study vaccine including gentamycin, neomycin or streptomycin or any other aminoglycoside. * History of Diabetes mellitus Type I or Type II. * Active Tuberculosis. * Hereditary angioedema, acquired angioedema, or idiopathic forms of angioedema. * Idiopathic urticaria within the last year. * Bleeding disorder diagnosed by a doctor or use of anticoagulant medications such as, warfarin, apixaban, dabigatran (eg, factor deficiency, coagulopathy, or platelet disorder requiring special precautions) or significant bruising or bleeding difficulties with IM injections or blood draws. * Major thrombotic event or heparin-induced thrombocytopenia or vaccine-induced thrombotic thrombocytopenia (VITT). * History of malignancy of any organ system, treated or untreated, within the past 5 years from screening. (If diagnosed malignancy is 5 or more years prior to enrollment and cured with no ongoing treatment it will NOT be considered an exclusion). * Seizure in the past 3 years or treatment for seizure disorder in the past 3 years. * Asplenia or functional asplenia. * Autoimmune disease/autoinflammatory condition. * Any medical, psychiatric, social condition, occupational reason, or other responsibility that, in the judgment of the investigator, is a contraindication to protocol participation or impairs a participant's ability to give informed consent. 7. Has a clinically significant acute illness (this does not include minor illnesses) or temperature ≥38.0°Celsius (≥100.4° Fahrenheit) within 24 hours of the planned dose of study vaccine, re-evaluation of eligibility may be performed at resolution of all signs and symptoms, and randomization at a later date is permitted at the discretion of the investigator and after consultation with the sponsor (as appropriate). 8. Receipt of any of the following substances: * COVID-19 vaccine that has not received emergency use authorization or approval per local regulatory agency. * Prior receipt of Ebola or Marburg vaccine. * Prior receipt of any adenoviral-vectored vaccine, adenovirus-based or adeno-associated viruses (AAV)-based gene therapies or treatments, including adenoviral COVID-19 vaccines or boosters. * Participant received an investigational drug (including investigational drugs for prophylaxis of COVID-19) within 28 days of dosing or within washout period (5 half-lives) of such drug or has used an invasive investigational medical device within 28 days of dosing. * Received investigational Ig or monoclonal antibodies within 3 months. * Received convalescent serum for COVID-19 treatment within 3 months. * Received an investigational vaccine within 3 months before the planned administration of the first dose of study vaccine. * Is currently enrolled or plans to participate in another investigational or interventional study during this study (observational/registry studies are allowed). 9. Use of immunomodulators or systemic glucocorticoids in daily doses of glucocorticoid equivalence \>20 mg of prednisolone in the last 90 days, and for periods exceeding 10 days. NSAIDS are permitted. 10. Receipt of blood products within 3 months prior to enrollment. 11. Current anti-tuberculosis prophylaxis or therapy. 12. Abnormality or permanent body art (such as tattoo) in deltoid region that would interfere with ability to observe or assess injection site reactions.