This investigation is aimed to assess the prevalence and severity of apical periodontitis (AP) in different stages of CKD patients and its impact on the systemic (nutritional and inflammatory) markers was compared to healthy individuals.
105 CKD patients (35 early (EG), 35pre-dialysis (PDG) and 35 hemodialysis (HDG)groups and 105 age and gender matched healthy controls were assessed for prevalence and severity of apical periodontitis and oral disease burden . Inflammatory (hsCRP and ferritin) and nutritional (urea and creatinine) markers were estimated and eGFR was calculated for the study population. Logistic regression was used to determine the possible association between CKD and AP in study population and Linear regression was performed to evaluate the possible association between systemic markers and endodontic burden (EB) in experimental group.
Study Type
OBSERVATIONAL
Enrollment
210
To observe levels of CKD markers :Levels of serum keratinise ,urea, eGFR, and assessment of Oral health status, apical periodontitis
estimation of hs-CRP levels, and assessment of Oral health status, apical periodontitis
PGIDS
Rohtak, Haryana, India
Periapical Index(PAI)
Periodical status will be assessed in periodical radiograph and scoring of periapical index will be done according to size and periphery of peri-apical radiolucency with coding 1 to 5
Time frame: 1 year
eGFR
BY BLOOD SAMPLE measured in mL/min/1.73m2
Time frame: 1 year
serum creatinine
BY BLOOD SAMPLE measured in mg/dL
Time frame: 1 year
hs-CRP
HIGH SENSITIVE C-reactive protein measured by ELISA kit in mg/L
Time frame: 1 year
Blood urea
measured by collecting blood sample in mg/dL
Time frame: 1 year
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