Treatment of Gingival Recession Defects Using Platelet-Rich Fibrin With an Allogenic Dermal Matrix

Inclusion Criteria: * Periodontally and systemically healthy adults * Full-mouth plaque score and full-mouth bleeding score ≤ 20% * Presence of at least one 3 mm or deeper gingival recession, with at least 1.5 mm of Keratinized tissue, and 1 mm of gingival thickness) requiring surgical intervention for root coverage * No interproximal attachment/bone loss * No prior experience of root coverage procedures within the last 1 year * The patient must be able to perform good oral hygiene Exclusion Criteria: * Contraindications for undergoing periodontal surgery * Teeth with more than Grade II mobility, or furcation involvement of Class III * Patients pregnant or attempting to get pregnant (self-reported), or nursing women * Untreated/active periodontitis, or other untreated acute infections at the surgical site * Untreated malignancies at the surgical site * Persistence of uncorrected gingival trauma from traumatic toothbrushing * Presence of severe tooth malposition, rotation or clinically significant super-eruption * Self-reported current smoking more than 10 cigarettes/day or pipe or cigar smoking, or active tobacco chewing, or chronic vaping * Patients with any known history of blood disorders or complications such as abnormal concentration of thrombin and factor XIII in plasma, or hemophilia * Patients with significant co-morbidities, such as obesity, uncontrolled diabetes, immunosuppression, severe endocrine-induced bone diseases, signs of malnourishment, those receiving immunosuppressive therapy, poor tissue oxygenation or perfusion, and pre- or post-operative radiation * Patients with known sensitivity to Polysorbate 20, Cefoxitin, Lincomycin, polymyxin B, Vancomycin