The aim of the study is to evaluate the effect of black seed oil on endothelial dysfunction, oxidative stress and quality of life in hemodialysis patients.
Evaluation of the effect of black seed oil in hemodialysis patients via: * Evaluation of serum Endothelin-1 levels * Evaluation of serum Malondialdehyde (MDA) levels * Evaluation of serum Total Antioxidant Capacity (TAC) levels * Evaluation of Quality of Life (QOL) * Evaluation of fatigue scale
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
Dietary supplement
placebo capsules same odor, color and size as the drug but without the active ingredient
Ain Shams University Hospital
Cairo, Egypt
serum Endothelin-1 (ET-1) level
marker of endothelial dysfunction
Time frame: 8 weeks
Serum malondialdehyde (MDA) and total antioxidant capacity (TAC)
markers of oxidative stress
Time frame: 8 weeks
Quality of life questionnaire
using validated Arabic version SF-36 questionnaire
Time frame: 4 weeks and 8 weeks
Fatigue severity
using the Multidimensional Fatigue Inventory (MFI)
Time frame: 4 weeks and 8 weeks
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