Gastric cancer patients after total gastrectomy will be randomized to oral nutritional supplement group or control group at discharge. Patients will receive 6 months of oral nutritional supplement or normal diet after discharge. The primary and secondary outcomes will be collected.
Gastric cancer patients after total gastrectomy at discharge, if she/he has nutrition risk (NRS2002≥3), then she/he will be randomized to oral nutritional supplement (ONS) group or control (C) group after discharge. In the ONS group, in addition to diet, and patients will also consume enteral nutritional powder (500ml/d，500kcal/d) lasted for 6 months. In the C group, patients will receive normal diet. Both groups will receive nutrition counseling. The primary and secondary outcomes will be collected.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
oral nutritional supplement
Jinling Hospital, China
Nanjing, Jiangsu, China
RECRUITINGincidence of sarcopenia 6-month after discharge
sarcopenia is defined as low skeletal muscle mass plus low muscle strength or low physical ability.
Time frame: up to 6 months.
incidence of sarcopenia 1 year after discharge
sarcopenia is defined as low skeletal muscle mass plus low muscle strength or low physical ability.
Time frame: up to 12 months.
unplanned readmission rate
readmission due to unplanned reason
Time frame: up to 6 months.
toxicity of chemotherapy graded according to the CTCAE, version 5.0
Chemotherapy toxicity will be monitored at end of each cycle during chemotherapy by investigators, and graded according to the CTCAE, version 5.0.
Time frame: up to 6 months.
Quality of life after discharge
Quality of life assessed by EORTC QLQ-C30
Time frame: up to 12 months.
Changes in BMI (weight and height will be combined to report BMI in kg/m^2)
nutritional status after discharge
Time frame: up to 12 months.
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