Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness

Beijing Tiantan Hospital200 enrolled

Overview

Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness based on Electroencephalography and Auditory Event-related Potentials

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Consciousness Disorder

Interventions

Different drug dosageDRUG

Choice of Anesthesia

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18 - 65 years old, native Chinese speaker, dextromanuality; * Chronic disorder of consciousness; * Spinal cord electrical stimulator implantation under general anesthesia; * Signed informed consent. Exclusion Criteria: * Continuous sedation was administered within 72 hours prior to the study; * Open head injury, parenchymatectomy and other damage of brain structural integrity; * The intracranial compliance decreased due to hydrocephalus and swelling; * Known hearing impairment; * Airway stenosis and various causes of severe ventilation or ventilation dysfunction; * Known or suspected cardiac dysfunction; * Allergic to intravenous general anesthetics; * Associated with other mental or neurological diseases; * Other reasons are not suitable to participate in this study.

Locations (1)

Beijing Tiantan Hospital, Capital Medical University

Beijing, China

RECRUITING

Outcomes

Primary Outcomes

EEG Spectral Characteristics

Characteristics of EEG power spectrum(for 1-30 Hz) in patients with chronic consciousness disorder under different doses of drugs

Time frame: During the trial(up to 3 hours for each subject)

Secondary Outcomes

Cortical Connectivity

Characteristics of the weighted phase lag index in patients with chronic consciousness

Time frame: During the trial(up to 3 hours for each subject)

Derived quantitative indicators

Characteristics of EEG derived quantitative indicators with chronic consciousness disorder during anesthesia recovery

Time frame: During the trial(up to 3 hours for each subject)

Characteristics of sleep

Characteristics of sleep cycle in patients with chronic disorders of consciousness

Time frame: During the trial(up to 24 hours for each subject)

Dynamic Patterns of Cortical Connectivity

The time-frequency characteristics of the weighted phase lag index in patients with chronic disorders of consciousness

Time frame: During the trial(up to 3 hours for each subject)

Rate of patients recovered consciousness after surgery

Rate of patients recovered consciousness 30 days, 90 days, 180 days after surgery

Time frame: During the trial(through study completion, 180 days)

Data from ClinicalTrials.gov

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