ME-344 and Bevacizumab in Previously Treated Metastatic Colorectal Cancer

Inclusion Criteria: * Age ≥18 years * Histological or cytological documentation of adenocarcinoma of the colon or rectum that is metastatic (all other histological types are excluded) * Subjects who progressed or demonstrated intolerability to prior standard approved therapies which include fluoropyrimidine, oxaliplatin, and irinotecan-based chemotherapies, cetuximab/panitumumab (if clinically indicated e.g., RAS wild-type tumors) PD-1 or BRAF inhibitors (if clinically indicated), and/or other checkpoint inhibitors in the metastatic setting. * Previous treatment with any investigational drug or anticancer treatment must be completed \>28 days or 5 half-lives, whichever is longer, before the first dose of study treatment. * Adequate bone marrow, liver, and renal function Exclusion Criteria: * Untreated brain metastases, spinal cord compression, or primary brain tumor * Symptomatic brain metastases, leptomeningeal disease, spinal cord compression, or primary brain tumor * Evidence of uncontrolled or unstable cardiovascular disease, myocardial infarction (within 6 months), unstable angina pectoris, congestive heart failure, serious arrhythmias requiring drug therapy * History of CNS disease * Bevacizumab or aflibercept therapy ≤ 3 weeks prior to starting study treatment * Peripheral neuropathy Grade ≥ 2 * Uncontrolled hypertension or diabetes mellitus, active peptic ulcers, unhealed wounds, clinically significant disease or systemic infections * Known seropositive for, or active infection with hepatitis B or C virus * Symptomatic or uncontrolled infection with human T-cell leukemia virus * Venous thromboembolism (unless appropriately treated and stable on anticoagulant for at least 2 weeks).