A prospective, randomized, controlled study to compare the efficacy and safety of underwater endoscopic mucosal resection and conventional endoscopic mucosal resection in removal of non-pedunculated colorectal polyps
* Patients are undergone colonoscopy at the Endoscopy department of Ho Chi Minh City University Medical Center. * Randomize patients with non-pedunculated polyp of 10mm or larger in size into 2 interventional groups based on Random function of Statistical Package for the Social Sciences (SPSS) 20.0, including (1) Group 1: Underwater endoscopic mucosal resection (UEMR) and (2) Group 2: Conventional endoscopic mucosal resection (CEMR). * The time of local recurrence assessment depends on the histopathology of polyps. Polyps with low grade dysplasia are followed up at 6 months, while polyps with high grade dysplasia are followed at 3 months. * Collecting variables which consist of primary and secodary outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
228
Group 1: Polyps are resected by UEMR Group 2: Polyps are resected by CEMR
University of Medicine and Pharmacy at Ho Chi Minh city
Ho Chi Minh City, Vietnam
RECRUITINGen bloc resection
Rate of en bloc resection for non-pedunculated colorectal polyps of 10 mm or more
Time frame: immediately after the procedure
Curative rate
Curative rate for non-pedunculated colorectal polyps of 10 mm or more
Time frame: through study completion, an average of 6 months
Complication rate
Rate of complications including bleeding, perforation
Time frame: up to 2 weeks
Local recurrence rate
Rate of local recurrence
Time frame: 6 months
Procedure time
Time for complete resection of polyps
Time frame: during the procedure
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