The objectives of the CAJESITO study are (i) to assess the tolerance of oral cashew nut immunotherapy, by describing the frequency and severity of allergic reactions during oral cashew nut immunotherapy and (ii )to assess the risk factors for severe allergic reactions during oral cashew nut immunotherapy (predictive factors, associated factors.
Study Type
OBSERVATIONAL
Enrollment
40
No intervention, it's an observational study
Number of allergic reaction
Time frame: during 6 months
Predictive factor of good tolerance
age at onset
Time frame: during 6 months
antibody variation
Modification of level of specific IgE and IGg4 with cashew nuts
Time frame: during 6 months
sustained unresponsiveness
Tolerance of 1, 2, 4, 8g in isolated doses and 15g in total cumulative dose of cashew nuts during an oral challenge test with cashew nuts 3 months after stopping the daily consumption of 2g of cashew nuts
Time frame: 9 months
oral tolerance of pistachio
Tolerance of 1, 2, 4, 8g in isolated doses and 15g in total cumulative dose of pistachio during an oral provocation test with pistachio 3 months after stopping the daily consumption of 2g of cashew nuts
Time frame: 6 months
Predictive factor of good tolerance
antecedent of severe allergic reaction
Time frame: 6 months
Predictive factor of good tolerance
initial reactogenic threshold
Time frame: 6 months
Predictive factor of good tolerance
presence atopy (asthma, food allergy or atopic dermatitis)
Time frame: 6 months
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Predictive factor of good tolerance
initial specific IgE and Ana o3 levels
Time frame: 6 months