Radiotherapy is one of the main treatments for head and neck Carcinoma. The incidence of radiotherapy-related adverse events is greater than 90%, and severe adverse events may lead to the interruption of radiotherapy. The management of nutritional, psychological, and rehabilitative issues in patients undergoing radiotherapy for head and neck cancer presents unique clinical challenges. We aimed to evaluate the efficacy of the SHINE-MDT (Supportive Holistic Interventions by Nurses and Experts via Multidisciplinary Team) in reducing radiotherapy interruptions and improving patients' quality of life (QoL) compared with usual care.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
233
On the basis of standard treatment, all patients were evaluated by senior practice nurses in the Department of Oncology in person at the time of enrollment (before radiotherapy) and once every week during radiotherapy, and once in person/over the phone at 1, 2, 3, and 6 months after radiotherapy.
West China Hospital, Sichuan University
Chengdu, Sichuan, China
Radiotherapy interruption rate
Interruption of radiotherapy was defined as the actual end date of radiotherapy minus the expected end date at least 5 days
Time frame: 5 days
Quality of life score (EORTC QLQ C30)
Quality of life score was calculated according to the European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Core 30 (EORTC QLQ C30)
Time frame: Weekly during radiotherapy and the first month post-treatment, and at 2, 3, and 6 months post-treatment
Quality of life score QLQ-HN35
Quality of life score was calculated according to the European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire QLQ-HN35
Time frame: Weekly during radiotherapy and the first month post-treatment, and at 2, 3, and 6 months post-treatment
Nutritional status (NRS 2002, PG-SGA)
Nutritional status was calculated according to Nutrition Risk Screening 2002 and Patient-Generated Subjective Global Assessment。
Time frame: Weekly during radiotherapy and the first month post-treatment, and at 2, 3, and 6 months post-treatment
Psychological status (DT, PHQ-9, HADS)
Psychological status was calculated according to Distress Thermometer (DT), Hospital Anxiety and Depression Scale (HADS), and Patient Health Questionnaire-9 (PHQ-9)
Time frame: Weekly during radiotherapy and the first month post-treatment, and at 2, 3, and 6 months post-treatment
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