To evaluate the effects of protein-enriched soup plus exercise on muscle mass and muscle strength. Besides, the investigators use the valued-based healthcare standard set as well as the Center for Epidemiological Studies-Depression, Charlson's comorbidity index Montreal Cognitive Assessment , and Mini Nutritional Assessment as outcome measures and to use the trial in validate additional supplement protein-enriched soup plus exercise could improve the vitality and health of mid-aged and old adults.
With aging, functions of every organs become to decline. Muscle mass, is one of the decline. According to previous research, adults would lose 40% among from aged 20 to 70. If muscle mass decline combining with the decline of muscle strength is so called Sarcopenia.When muscle mass decline, infectious risk gets higher, and resilience after illness gets lower. In addition, activity and life quality are also responsible for falling, cognitive difficulty, disability and mortality among seniors. We hope to find out the etiologies of Sarcopenia through this program and develop prevention strategy and model to mollify the the negative effect of rapid aging society.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
100
The participants in experimental group have a protein-enriched soup a day and do exercise a week
National Yang Ming Chiao Tung University
Taipei, Taiwan
Changes from baseline physical function after 12 weeks
measured by hand grip, 6-minute walk distance, six-meter walking speed, 5 times sit-to-stand
Time frame: baseline, 4, 12 weeks
Change from baseline numbers of Complete blood count after 12 weeks
Change from baseline numbers of Complete blood count after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of Albumin after 12 weeks
Change from baseline concentration of Albumin after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of Alanine Aminotransferase (ALT) after 12 weeks
Change from baseline concentration of Alanine Aminotransferase (ALT) after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of Aspartate Aminotransferase (AST) after 12 weeks
Change from baseline concentration of Aspartate Aminotransferase (AST) after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of blood urea nitrogen after 12 weeks
Change from baseline concentration of blood urea nitrogen after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of Creatinin after 12 weeks
Change from baseline concentration of Creatinin after 12 weeks
Time frame: baseline, 4, 12 weeks
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Change from baseline concentration of Fasting glucose after 12 weeks
Change from baseline concentration of Fasting glucose after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of Fasting insulin after 12 weeks
Change from baseline concentration of Fasting insulin after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of high-sensitivity C-reactive protein after 12 weeks
Change from baseline concentration of high-sensitivity C-reactive protein after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of 25-(OH)-Vit. D after 12 weeks
Change from baseline concentration of 25-(OH)-Vit. D after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of Leptin after 12 weeks
Change from baseline concentration of Leptin after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of urine protein after 12 weeks
Change from baseline concentration of urine protein after 12 weeks
Time frame: baseline, 4, 12 weeks
Changes form baseline QUALITY OF LIFE after 12 weeks
measured by the 36-Item Short Form Health Survey (SF-36), ranged 0-100, higher values represent a better condition
Time frame: baseline, 4, 12 weeks
Change from baseline Nutrition intake after 12 weeks
measured by Mini-nutritional assessment questionnaire. ranged 0-30, higher values represent a better condition
Time frame: baseline, 4, 12 weeks
Change from baseline depression after 12 weeks
measured by the Center for Epidemiological Studies-Depression (CES-D) ranged 0-60, higher values represent a worse condition
Time frame: baseline, 4, 12 weeks
Change from baseline cognitive ability after 12 weeks
measured by Montreal Cognitive Assessment (MoCA) , ranged 0-30, higher values represent a better condition
Time frame: baseline, 4, 12 weeks
Change from baseline body composition analysis after 12 weeks
measured by RASM
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of Total Cholesterol after 12 weeks
Change from baseline concentration of Total Cholesterol after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of Triglyceride after 12 weeks
Change from baseline concentration of Triglyceride after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of high-density lipoprotein cholesterol after 12 weeks
Change from baseline concentration of high-density lipoprotein cholesterol after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of low-density lipoprotein cholesterol after 12 weeks
Change from baseline concentration of low-density lipoprotein cholesterol after 12 weeks
Time frame: baseline, 4, 12 weeks
Change from baseline concentration of dehydroepiandrosterone after 12 weeks
Change from baseline concentration of dehydroepiandrosterone after 12 weeks
Time frame: baseline, 4, 12 weeks
Change in International Physical Activity Questionnaire (IPAQ) after 12 weeks
Change in physical activity measured by IPAQ, indicates that spent being physically active thin the prior 7 days.There are no established thresholds for presenting MET-minutes, the IPAQ Research Committee proposes that reported as comparisons of median values and interquartile ranges for different populations from baseline to 12 weeks in all participants.
Time frame: baseline, 4, 12 weeks