Fluid Challenge Impact in the Portal Vein Pulsatility Depending on the Fluid Responsivness Status

Hospices Civils de Lyon36 enrolled

Overview

Portal vein pulsatility index is a marker of venous congestion evaluated by point of care ultrasound. It is associated with acute kidney injury, especially in critically ill patients. It may be considered as a dynamic marker. The investigators hypothesized that portal vein pulsatility index is higher after a fluid challenge only in patient without preload dependence in critically ill patients with cardiovascular insufficiency.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiovascular Insufficiency Venous Congestion

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * vasopressor requirement to maintain mean arterial pressure \>65mmHg AND * at least one of the following criteria: * arterial lactate \>2mmol/L; * capillary refill time \>3s; * mottling score \>1; * diuresis \<0,5mL/h for more than 6hours. Exclusion Criteria: * Diameter of vena cava \<20mm * Cirrhosis * Pregnancy * Severe acute pulmonary edema * Phototype 4 or 5 * Patient opposition to participate

Locations (1)

Hôpital cardiologique Louis Pradel

Bron, France

Outcomes

Primary Outcomes

Portal vein pulsatility index variation induced by the fluid challenge (%), defined by: Portal vein pulsatility index before the fluid challenge - portal vein pulsatility index after the fluid challenge.

Portal vein pulsatility index is defined as the (maximal velocity - minimal velocity) / maximal velocity assessed with doppler in portal vein estimated with point of care ultrasound.

Time frame: One hour

Data from ClinicalTrials.gov

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