Magrolimab Plus Intensive Chemotherapy in Newly Diagnosed AML or HR-MDS

Inclusion Criteria: * AML or MDS-IB2 according to WHO 2022 criteria * For both MDS and AML: "Intermediate" or "adverse risk" genetic changes according to ELN 2022 category * Eligible for and intention to undergo intensive chemotherapy (IC) (CPX-351 or "7+3") followed by allogeneic HSCT, as judged by the investigator Exclusion Criteria: * Patients harboring a FLT3mut, regardless of FLT3-ITD or FLT3-TKD mutation status and intended to receive midostaurin during induction and consolidation * Patients intended to receive gemtuzumab-ozogamicin during intensive chemotherapy * Patient does not accept bone marrow sampling during screening, during and after the treatment * Patient does not accept several blood samplings during screening, treatment and after the treatment * Patients who are not eligible for standard intensive chemotherapy as assessed by the treating physician * Previous anthracycline-containing chemotherapy (Exception: cumulative dose for 1 cycle of planned induction therapy (CPX-351 or "7+3") not reached) * Any prior treatment for AML or MDS (except for hydroxyurea or treatment for low-risk MDS e.g. growth factors) or prior treatment with CD47 or SIRPα-targeting agents, including magrolimab * Inadequate organ function as defined as any criterion in the list below: 1. Congestive heart failure or documented cardiomyopathy with an EF ≤50% 2. Documented pulmonary disease with DLCO ≤65% or FEV1 ≤65%, or dyspnea at rest or requiring oxygen, or any pleural neoplasm or uncontrolled lung neoplasm 3. On dialysis and age older than 60 years or uncontrolled renal carcinoma 4. Aspartate aminotransferase (AST)/serum glutamic oxaloacetic transaminase (SGOT) and alanine aminotransferase (ALT)/serum glutamic pyruvic transaminase (SGPT) \> 5× upper limit of normal (ULN) or liver cirrhosis Child B or C or any biliary tree carcinoma or uncontrolled liver carcinoma or acute viral hepatitis 5. Bilirubin \> 1.5× ULN, or 3.0× ULN and primarily unconjugated if patient has a documented history of Gilbert's syndrome or genetic equivalent 6. Serum creatinine \> 1.5× ULN or calculated glomerular filtration rate (GFR) \< 40 mL/min/1.73 m² * ECOG performance status of ≥ 3 * Medical conditions other than MDS-IB-2 or AML with an estimated life expectancy below 3 months * Relapsed or primary refractory AML * Acute promyelocytic leukemia * Known severe cardiopulmonary disease (e.g., unstable angina, congestive heart failure with an EF ≤50%, myocardial infarction within 6 months prior to screening, symptomatic cardiomyopathy, clinically significant arrhythmia17, clinically significant pulmonary hypertension requiring pharmacologic therapy) * Uncontrolled high blood pressure (i.e., systolic blood pressure \> 180 mm Hg, diastolic blood pressure \> 95 mm Hg)18 * Known prolonged rate-corrected QT interval ≥ 500 msec, calculated according to Fridericia's formula * Active uncontrolled infection or severe infectious disease, such as severe pneumonia, meningitis, or septicemia * Known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial. * Known active Human Immunodeficiency Virus infection (HIV 1/2 antibodies) with detectable viral load * Known active Hepatitis B (i.e., HBsAg reactive) or Hepatitis C (i.e., HCV RNA \[qualitative\] is detected). * Major surgery within 14 days of registration or a scheduled surgery during study period, depending on investigator decision * Known uncontrolled central nervous system (CNS) involvement of MDS-IB-2 or AML (assessment by lumbar puncture is not mandatory for screening) * Diagnosis or treatment for another malignancy within 1 year before registration and currently not in complete remission * Any evidence of residual disease of another malignancy * Patients with uncontrolled coagulopathy or bleeding disorder * History or current evidence of any condition, therapy, or laboratory abnormality that might the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator * Current or planned pregnancy or nursing women (negative urine or serum pregnancy test within 3 days prior to receiving study treatment is needed. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test must be performed.) * Female patients of childbearing potential, who are not using or not willing to use one highly effective method and one additional effective (barrier) method of contraception, at the same time, from the time of signing the informed consent through 6 months after the last dose of study drug. Note: Abstinence is acceptable if this is the usual lifestyle and preferred contraception for the subject. * Female patients who intend to donate eggs (ova) during the course of this study or 4 months after receiving their last dose of study drug(s). * Male patients, who do not agree to use an adequate method of contraception, starting with the first dose of study therapy during the entire study treatment period and through 3 months after the last dose of study drug. Note: Abstinence is acceptable if this is the usual lifestyle and preferred contraception for the subject. * Male patients who intend to donate sperm during the course of this study or 4 months after receiving their last dose of study drug(s). * Age under 18 years at registration * Subject is unable to understand the nature, scope, significance and consequences of this clinical trial or has no legal capacity * Simultaneous participation in another interventional clinical trial or participation in any clinical trial involving administration of an investigational medicinal product within 30 days prior to MAGROLIC trial registration