Application of Sodium Bicarbonate Ringer's Solution in Laparoscopic Hepatectomy

The First Affiliated Hospital with Nanjing Medical University100 enrolled

Overview

Compared the effects of Sodium bicarbonate Ringer's solution and lactate Ringer's solution on the internal environment and hemodynamics of patients during laparoscopic liver resection, to observe the application prospect of sodium bicarbonate Ringer's solution in Laparoscopic hepatectomy.

The study was a single-center prospective randomized controlled study. A total of 100 patients undergoing laparoscopic hepatectomy under general anesthesia were randomly divided into 2 groups: Group A, sodium bicarbonate Ringer's solution group(n=50); Group B, Lactate Ringer's solution group (intraoperative crystal fluid dilatation was lactate ringer's injection, n=50); Collect patients' arterial blood gas, blood pressure, heart rate, peripheral vascular resistance, heart rate, blood vessels, the active drug usage, 5% sodium bicarbonate injection usage, inflammation factors, transaminase, creatinine, etc. with the point of preoperative (T0), during liver specimens resected(T1), after liver specimens resected(T2), and the end of surgery (T3). Then statistical analysis and observe the application prospect of sodium bicarbonate Ringer's injection in Laparoscopic hepatectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

100

Conditions

Hepatic Ischemia

Interventions

sodium bicarbonate Ringer's solutionDRUG

Sodium bicarbonate Ringer's solution was used in Group A as intraoperative intravenous fluids. Lactate Ringer's solution was used in Group B as intraoperative intravenous fluids.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. ≥18 years old, 2. patients who plan to undergoing laparoscopic hepatectomy ; 3. Willing to sign informed consent. Exclusion Criteria: 1. age \<18 years 2. pregnancy 3. active cardiac conditions (unstable coronary syndromes, decompensated heart failure, significant arrhythmias, severe valvular disease, history of congestive heart failure) 4. history of significant cerebrovascular disease 5. restrictive or obstructive pulmonary disease 6. uncontrolled hypertension 7. renal dysfunction (glomerular filtration rate \<60 mL/min), 8. evidence of hepatic metabolic disorder (bilirubin \>35 mmol/L) 9. presence of active infection

Locations (1)

Shijiang Liu

Nanjing, Jiangsu, China

RECRUITING

Outcomes

Primary Outcomes

lactic values

to compare the conditions of acid-base balance and internal environment between the two groups

Time frame: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 1 month.

Secondary Outcomes

Amount of sodium bicarbonate injection (ml)

Time frame: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 1 month.

Value of pH