IN10018 Combination Therapy in Previously-treated Locally Advanced or Metastatic Solid Tumor Patients

Inclusion Criteria 1. Male or female, and aged 18 - 75 years at the time of signing the informed consent. 2. Has ability to understand and willingness to sign informed consent(s). 3. Histologically confirmed locally advanced or metastatic solid tumors: 1. Cohort 1: Histologically-confirmed Locally advanced or metastatic triple-negative breast cancer. 2. Cohort 2: Histologically or cytologically confirmed recurrent or metastatic head and neck squamous cell carcinoma. 3. Cohort 3 and 4: Histologically confirmed epithelia ovarian cancer, fallopian tube cancer or primary peritoneum cancer with the subtype limited to high-grade serous carcinoma (HGSC) only. 4. Cohort 5: Histologically confirmed extensive-stage small cell lung cancer (according to the Veteran's Administration Lung Cancer Study Group (VALG) classification system). 5. Cohort 6: other Histologically confirmed locally advanced or metastatic solid tumors except cohort 1-5. 4. Have received at least 1 line of standard therapy for locally advanced or metastatic solid tumors and have failed or are not tolerable. 5. At least one measurable lesion can be accurately measured per RECIST 1.1 as assessed by investigator. 6. ECOG performance status of 0 or 1. 7. Life expectancy of at least 3 months as assessed by investigator. 8. Adequate bone marrow, liver, renal, and coagulation function within 7 days prior to first dose of study treatment. 9. Must have recovered from all AEs due to previous therapies to ≤ Grade 1 (CTCAE 5.0) or stable status as assessed by investigator. Exclusion criteria 1. Has had major surgery or significant traumatic injury within 28 days prior to first dose of study treatment, or diagnostic biopsies within 14 days prior to first dose of study treatment. 2. Has received prior systemic anticancer therapy such as chemotherapy, biological therapy, endocrine therapy, immunotherapy, etc. within 4 weeks before the first dose. 3. History of autoimmune disease requiring systemic therapy within the past 2 years, including but not limited to autoimmune thyroid disease, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease. 4. Has interstitial pneumonia currently. 5. Has received prior treatment of any FAK inhibitor. 6. Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis. 7. Has a prior history of malignancy other than the study disease. 8. Clinically symptomatic pleural effusion, pericardial effusion, or ascites, or those who have received or necessary for drainages within 3 months prior to the first dose of study treatment. 9. Has malabsorption syndrome or inability to take oral medication. 10. Has clinical or radiologic evidence of bowel obstruction, or prior recurrent bowel obstruction with the cause not eliminated within 3 months prior to the first dose of study treatment. 11. Has any active infection requiring systemic therapy within 14 days prior to the first dose of study treatment. 12. Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the subject's participation for the full duration of the study, or is not in the best interest of the subject to participate, in the opinion of the treating investigator. 13. Known allergy or hypersensitivity to IN10018, PLD, or Toripalimab or their ingredients. 14. Pregnant or lactating women. 15. Has received prior cumulative doxorubicin or equivalent anthracyclines doses of 360 mg/m2 or more. 16. Has received systemic treatment of CYP3A4, CYP2D6 or P-gp strong inhibitors/inducers within 14 days prior to the first dose of study treatment, or anticipation of the systemic treatment of these drugs during Treatment Phase.