Improving the Intraoperative Diagnosis Accuracy of Invasiveness for Small-sized Lung Adenocarcinoma

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology3,000 enrolled

Overview

The goal of this observational study is to improve the intraoperative diagnosis accuracy of invasiveness for small-sized lung adenocarcinoma by combining multi-modal information. The main question it aims to answer is whether multi-modal information have great value of prediction on the invasiveness for small-sized lung adenocarcinoma. Since a promising limited resection is largely based on intraoperative frozen section diagnosis, there is a growing demand on the high-accuracy of timely pathology diagnosis. The multi-modal information of participants will be collected retrospectively.

Study Type

OBSERVATIONAL

Enrollment

3,000

Conditions

Lung Adenocarcinoma, Stage I

Interventions

Invasiveness diagnosisDIAGNOSTIC_TEST

To predict the invasiveness of patients with small-sized lung adenocarcinoma intraoperatively based on multi-modal information.

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: CT examination within 3 months before surgery Patients with operable clinical stage I lung cancer No previous treatment in the lungs or any other organ ≥ 20 years and ≤ 80 years old Tumor less than 3cm in diameter on thin-slice (0.625-1 mm) CT images Lung adenocarcinoma confirmed by surgical resection and histopathological diagnosis Exclusion Criteria: Marked artifacts on CT images History of preoperative treatment Incomplete clinical information or DICOM images History of other malignant tumors Lung cancer associated with cystic airspaces

Outcomes

Primary Outcomes

Final pathology diagnosis of the paraffin section stained with HE

The final pathology diagnosis after resection

Time frame: Immediately after operation