This trial investigates whether supervised training in combination with hormonal substitution therapy has an impact on body composition, cardiovascular risk, risk for dementia, osteoporosis and insulin sensitivity in postmenopausal women.
270 postmenopausal women will be included. Each woman will perform a 12 to 24 weeks sports program with supervised training exercises.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
390
The intervention consists of a supervised exercise program
Subjects take hormonal substitution therapy per standard of care
Ghent University Hospital - Women's Clinic
Ghent, Belgium
RECRUITINGEvaluation of the cardiovascular risk
The cardiovascular risk will be estimated by blood- and urine analysis, blood pressure and a AGE (i.e. Advanced Glycation End products)-reader. There are three timepoints of measurement; once at inclusion, once at 12 weeks, and once at 24 weeks.
Time frame: +12 weeks; +24 weeks
Evaluation of the insulin sensitivity
The insulin sensitivity will be estimated by blood- and urine analysis and a AGE (i.e. Advanced Glycation End products)-reader. There are three timepoints of measurement; once at inclusion, once at 12 weeks, and once at 24 weeks.
Time frame: +12 weeks, +24 weeks
Evaluation of the body composition
The body composition will be measured using bioimpedance technology (Tanita-scale). The body composition will be measured three times; once at inclusion, once at 12 weeks and once at 24 weeks.
Time frame: +12 weeks; +24 weeks
Evaluation of the muscle mass
The musle mass will be evaluated by performing a maximal effort test (i.e. cycling test). This test will be performed three times; once at inclusion, once at 12 weeks, and once at 24 weeks.
Time frame: +12 weeks; +24 weeks
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