This clinical trial aims to test the effect of acupuncture in patients with schizophrenia-related central obesity. The main question it aims to answer is: • The effect, safety, and maintenance of acupuncture on schizophrenia-related central obesity. Participants will receive acupuncture treatment on purpose acupoints, acupuncture on acupoint peripheries, or fake acupuncture treatment on purpose acupoints for 20 weeks. And they need three follow-up visits during the treatment period and two follow-up visits after treatment. Researchers will compare the waist circumstance of these three groups to see if the purpose acupoints are valid for schizophrenia-related central obesity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
150
All the groups receive respective treatment 3 times a week for the first eight weeks, twice a week for another 8 weeks, and once a week for the last 4 weeks.
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China
RECRUITINGShanghai Huangpu Mental Health Center
Shanghai, Shanghai Municipality, China
RECRUITINGChange from Baseline Waist Circumference at 8 weeks, 16 weeks, 20 weeks, 32 weeks, respectively
Waist Circumference in centimiter
Time frame: Baseline, 8 weeks, 16 weeks, 20 weeks, 32 weeks
Change from Baseline Body Weight Index at 8 weeks, 16 weeks, 20 weeks, 32 weeks, respectively
weight and height will be combined to report BMI in kg/m\^2
Time frame: Baseline, 8 weeks, 16 weeks, 20 weeks, 32 weeks
Change from Baseline Hip Circumference at 8 weeks, 16 weeks, 20 weeks, 32 weeks, respectively
Hip Circumference in centimiter
Time frame: Baseline, 8 weeks, 16 weeks, 20 weeks, 32 weeks
Change from Baseline both Blood Pressure at 8 weeks, 16 weeks, 20 weeks, 32 weeks, respectively
both Blood Pressure in mm/Hg
Time frame: Baseline, 8 weeks, 16 weeks, 20 weeks, 32 weeks
Change from Baseline Blood Triglyceride at 16 weeks, 32 weeks, respectively
Blood Triglyceride in mmol/L
Time frame: Baseline, 16 weeks, 32 weeks
Change from Baseline Blood Total Cholesterol at 16 weeks, 32 weeks, respectively
Total Cholesterol in mmol/L
Time frame: Baseline, 16 weeks, 32 weeks
Change from Baseline Blood Low-density Lipoprotein at 16 weeks, 32 weeks, respectively
Blood Low-density Lipoprotein in mmol/L
Time frame: Baseline, 16 weeks, 32 weeks
Change from Baseline Blood High-density Lipoprotein at 16 weeks, 32 weeks, respectively
Blood High-density Lipoprotein in mmol/L
Time frame: Baseline, 16 weeks, 32 weeks
Change from Baseline Blood Glucose at 16 weeks, 32 weeks, respectively
Blood Glucose in mmol/L
Time frame: Baseline, 16 weeks, 32 weeks
Change from Baseline Positive And Negative Syndrome Scale at 8 weeks, 20 weeks, 32 weeks, respectively
The Positive And Negative Syndrome Scale is used for valuation of positive symptom, negative symptom and general symptom of patients with schizophrenia. The score range of Positive And Negative Syndrome Scale is 0 to 150. The higher the score, the more severe the psychiatric symptoms.
Time frame: Baseline, 8 weeks, 20 weeks, 32 weeks
Change from Baseline Clinical Global Impression at 8 weeks, 20 weeks, 32 weeks, respectively
The Clinical Global Impression evaluates the severity of ilness, global improvement and efficacy index. The score range of severity of ilness is 0 (none) to 7 (extremly severe). The score range of global improvement is 0 (none) to 7 (seriously deteriorated). The score range of efficacy index is 0 (none) to 4 (effective and no adverse effect).
Time frame: Baseline, 8 weeks, 20 weeks, 32 weeks
Change from Baseline Personal and Social Performance Scale at 8 weeks, 20 weeks, 32 weeks, respectively
The score range of Personal and Social Performance Scale is 1 to 100. The higher score, the better personal and social performance.
Time frame: Baseline, 8 weeks, 20 weeks, 32 weeks
Change from Baseline Appetite visual analogue scale at 8 weeks, 20 weeks, 32 weeks, respectively
The score range of Appetite visual analogue scale is 0 to 10. The higher score, the better appetite.
Time frame: Baseline, 8 weeks, 20 weeks, 32 weeks
Change from Baseline Treatment Emergent Symptom Scale at 8 weeks, 16 weeks, 20 weeks, 32 weeks, respectively
The Treatment Emergent Symptom Scale contains 34 different common adverse effects in psychiatry patients. Each adverse effect can be assessed from three aspects, which are serverity, relationship with medications, and mesurement taken. The score range of serverity is 0 (none) to (servere). The range of relationship with medication is none, basicly (likelihood 10%) , maybe (likelihood 10%-50%), very likely (likelihood 50%-80%), definitely (likelihood over 90%). The score range of measurement taken is 0 (none) to 5 (stop medication).
Time frame: Baseline, 8 weeks, 16 weeks, 20 weeks, 32 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.