Association Between Fibrinogen-to-albumin Ratio and Delirium After Deep Brain Stimulation Surgery in Parkinson's Disease

Changhai Hospital226 enrolled

Overview

Postoperative delirium (POD) remains one of the most common neuropsychiatric complications after deep brain stimulation (DBS) surgery. The fibrinogen-to-albumin ratio (FAR) has been shown to significantly correlate with prognosis of many diseases associated with inflammation, but the relationship between FAR and POD is unclear. The investigators aimed to investigate the association between POD and FAR in Parkinson's disease (PD) patients receiving DBS surgery. For this aim, the present study was conducted to provide a new method for the early recognition and perioperative management of delirium after DBS surgery in PD patients.

Study Type

OBSERVATIONAL

Enrollment

226

Conditions

Parkinson Disease Deep Brain Stimulation Postoperative Delirium

Eligibility

Sex: ALLMin age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Over 55 years old * American Society of Anesthesiologists (ASA) physical status I-III * Bilateral subthalamic nucleus deep brain stimulation surgery Exclusion Criteria: * Preoperative delirium * Missing preoperative laboratory parameters on fibrinogen or albumin * Persistent infectious diseases * Coagulopathy and autoimmune-illness or malignancies

Locations (1)

Outcomes

Primary Outcomes

CAM score

Positive CAM score means that patient developed delirium after surgery. While negative CAM score means that patient did not suffer from delirium after surgery.

Time frame: Before surgery

CAM score

Positive CAM score means that patient developed delirium after surgery. While negative CAM score means that patient did not suffer from delirium after surgery.

Time frame: Postoperative day 1

CAM score

Positive CAM score means that patient developed delirium after surgery. While negative CAM score means that patient did not suffer from delirium after surgery.

Time frame: Postoperative day 2

CAM score

Positive CAM score means that patient developed delirium after surgery. While negative CAM score means that patient did not suffer from delirium after surgery.

Time frame: Postoperative day 3

Secondary Outcomes

Mini-mental State Examination (MMSE) score

MMSE score ranges from 0 to 30 and higher score means better cognitive function.

Time frame: Before surgery

MMSE score

MMSE score ranges from 0 to 30 and higher score means better cognitive function.

Time frame: Postoperative 24 hour

MMSE score

MMSE score ranges from 0 to 30 and higher score means better cognitive function.

Time frame: postoperative 72 hour

The level of fibrinogen-to-albumin ratio (FAR) in peripheral blood.

The FAR was calculated as fibrinogen / albumin.

Time frame: Before surgery