Prospective Study of Detection of Sarcopenia in Clinical Practice for Patient With Ovarian or Endometrial Cancer

Overview

Prospective monocentric study, non-randomized of the detection of sarcopenia in clinical practice in patients with ovarian or endometrial cancer requiring systemic oncological treatment. main question : Identify the criteria correlated with the presence of sarcopenia (defined by the measurement of the IMS by the CT-X method in L3) among the impedancemetry and the HAS malnutrition criteria. Data collection will be done at 6 months, 12 months after the date of inclusion.

Primary objective:Identify the criteria correlated to the presence of sarcopenia (defined by the measurement of the IMS by the CT-X method in L3) among the impedancemetry and the HAS malnutrition criteria Main judgment criteria : Comparison between the groups of patients with sarcopenia (Morphometric measurement of the musculoskeletal surface index \<39cm²/m² in L3 cross section) and without sarcopenia of the different evaluation criteria: * Impedancemetry values:: muscle mass index in kg/m2 (IMS), fat-free mass in kg/m2 and metabolic activity index (phase angle) * Percentage of weight loss * BMI \< 18.5 kg/m2 * Quantified reduction in muscle mass and/or function for patients \< 70 years old * Quantified reduction in muscle mass and function for patients \> 70 years old * Physical tests: walking speed and "hand grip" dynamometer secondary objectives:- Proposal of a composite score for the detection of sarcopenia usable in clinical routine * Evaluation of nutritional intake * Evaluation of the severity of undernutrition * Verification of a correlation between the sarcopenia indices of ovarian and endometrial cancer * Evaluate tolerance profiles to systemic treatments with regard to sarcopenia figures * Assess the relationship between PFS, OS and sarcopenia index in cancer diagnosis secondary judgment criteria : * Statistical analysis of sarcopenia and undernutrition data * Quantification of ingestates (SEFI scale) +/- intake of oral nutritional supplement * Serological tests: NFS, CRP and Albuminemia * Comparison of sarcopenia index figures between ovarian and endometrial cancer * Collection of the grades of toxicities and adverse events to systemic treatments in parallel with the measurement of sarcopenia. * Correlation between progression-free survival, death and sarcopenia index at cancer diagnosis