Effects of Dietary Nitrate Intake on Cardiovascular Performance in Response to Hand Grip Test in Bodybuilders

University of Sao Paulo13 enrolled

Overview

Through a randomized, crossover, double-blind, placebo-controlled clinical trial, 20 bodybuilders will participate a acute-day trial with two intervention protocols: 1) placebo and 2) nitrate; in which will ingest beet juice with or without NO3 in its composition with a 7-day washout interval.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Steroid Abuse Cardiovascular Abnormalities

Interventions

Beetroot juice rich in nitrateDIETARY_SUPPLEMENT

The participant will intake beetroot juice rich in NO3 (800mg). Two hours after intake the last bottle of juice, the participants will go to the laboratory for the handgrip and cardiovascular tests evaluation. Before crossover protocol a 7-day washout interval will be given for the purification of the compounds provided by the protocols.

Beetroot juice depleted in nitrateDIETARY_SUPPLEMENT

The participant will intake beetroot juice depleted in NO3. Two hours after intake the last bottle of juice, the participants will go to the laboratory for the handgrip and cardiovascular tests evaluation. Before crossover protocol a 7-day washout interval will be given for the purification of the compounds provided by the protocols.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Anabolic steroid use in the past or actually; * Participation at least one bodybuilding competition; Exclusion Criteria: * Previous history of acute myocardial infarction and/or stroke; * Allergy or intolerance to nitrate, gluten, or milk; * Medications (proton pump inhibitors, beta-blockers, calcium channels antagonists).

Locations (1)

EEFERP - USP / Laboratório de Fisiologia do Exercício e Metabolismo

Ribeirão Preto, São Paulo, Brazil

Outcomes

Primary Outcomes

1. Values of systolic and diastolic blood pressure (mmHg)

Time frame: up to 2 years

Secondary Outcomes

Plasmatic concentrations of nitrate and nitrite (mmol/L)

Time frame: up to 2 years

Values of heart rate variability (ms)

Time frame: up to 2 years

Macrovascular function (Flow mediated dilatation%)

Time frame: up to 2 years

Values of heart rate (beats per minute)

Time frame: up to 2 years

Values of hand grip strength (kgF)

Time frame: up to 2 years

Data from ClinicalTrials.gov

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