A Study of the Absorption, Metabolism and Excretion of [14C]XZP-3621 in Human

Inclusion Criteria: * Inclusion Criteria: A subject will be eligible for study participation if he meets the following criteria: 1. healthy male volunteers between the ages of 18 to 45 years old, inclusive 18 and 45; 2. Body weight \>=50 kg, Body mass index (body weight(kg)/hight2(m2)) between 19 and 26 kg/m2 (inclusive); 3. Male subjects of reproductive potential with partners will be instructed to, and must be willing to practice a highly effective method of birth control for the duration of the study and continuing 1 year after discontinuing treatment with the investigational product. Highly effective methods of birth control include using condom, contraceptive sponge, contraceptive gel, contraceptive film, intrauterine device, oral or injectable contraceptive pill, hypodermic implants or others; 4. Must understand, and voluntarily sign the informed consent, comply with the requirements of the study. Exclusion Criteria: * A subject will not be eligible for study participation if he meets any of the exclusion criteria: 1. Allergies, have allergies to two or more drugs or foods; or have known allergies to the components of the test drug; 2. Clinically significant medical history or findings in physical examination, vital signs, or laboratory test results prior to study start; 3. Clinically significant of ophthalmologic examinations; 4. Positive test for HBsAg, HBeAg, anti-HCV, anti-HIV or syphilis antibody; 5. History of or current swallowing disorder, active gastrointestinal diseases, or other diseases that significantly affect absorption, distribution, metabolism and excretion of drugs; 6. History of or current clinically significant cardio, pulmonary, endocrine, metabolism, renal, hepatic, gastrointestinal, dermatology, infection, hematology, neurological, mental disease or disorder; 7. Chronic constipation or diarrhea, irritable bowel syndrome, inflammatory bowel disease,Hemorrhoids or perianal disease with regular/perianal bleeding; 8. Received major surgery within 6 months prior to the screening period or surgical incisions were not fully healed; 9. Smoking (\> 5 cigarette / day), drinking (\> 14 units, pure alcohol / week, equivalent to 360 ml beer/unit, or 45 ml low-alcohol liquor) within 3 months prior to the screening period or Positive screening tests for alcohol,Subjects should avoid smoking and drinking during the clinical trail; 10. Participation in an investigational drug or device study within 3 months prior to screening period; 11. Subjects who have participated in radiolabeled clinical study within 1 year prior to screening period; 12. History of abusing drugs(MOP, METmAMP, MTD, THC, AMP positive) within 1 year prior to screening period; 13. Have donated 400ml or more of blood or plasma 3 months prior to the study drug administration; 14. Received any drug within 14 days before taking the investigational drug, including any prescription drug, OTC drug or herbal drug; 15. Use of any metabolic inducers (including herbals such as St. John's Wort) or inhibitors within 14 days before the first dose of study medication; 16. Failure to comply with clinical study protocols, such as non-cooperation, follow-up visit and completion of entire study; 17. Vaccination was administered within 1 months prior to screening or during screening; 18. Significant radiation exposure within one year prior to drug administration (more than 2 exposures from chest X-ray or CT scan, or barium meal examination and radiation-related occupations); 19. Investigators think that subjects are not suitable to participate in the study.