Effect of Physical Activity Pattern on Cardiometabolic Health

Brigham and Women's Hospital26 enrolled

Overview

The goal of this study is to understand the interaction between the circadian system and physical activity. Participants will: * complete 2 inpatient stays * perform moderate exercise * be provided with identical meals * have frequent blood draws * provide urine and saliva samples

The endogenous circadian system (i.e., an internal biological rhythm) plays an important role in regulating blood glucose, blood pressure, and energy expenditure. Physical activity improves health and reduces the risk for cardiovascular diseases and type 2 diabetes. The goal of this study is to understand the interaction between the circadian system and physical activity. We aim to test whether such relationship between the circadian system and physical activity can be used to enhance the health benefits of physical activity.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Life Style

Interventions

Exercise interventionBEHAVIORAL

Research participants will be assigned to two exercise conditions.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18-45 yr old * Body mass index (BMI) 18.5 - 34.9 kg/m2 * No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.) * Willing to adhere to the protocol requirements for the duration of the study Exclusion Criteria: * Currently smoking/vaping or 5 or more years of smoking/vaping * Currently pregnant or breastfeeding * History of drug or alcohol dependency * History of psychiatric illness or disorder * Any hospitalization due to COVID-19 * Inability to exercise for any reason * Any known contraindication to exercise testing based on current ACSM guidelines

Locations (1)

Brigham and Women's Hospital

Boston, Massachusetts, United States

RECRUITING

Outcomes

Primary Outcomes

glucose level

mean glucose level after exercise session

Time frame: 24-hour test period after exercise

mean arterial pressure

mean arterial pressure after exercise session

Time frame: 24-hour test period after exercise

Secondary Outcomes

insulin sensitivity index

Oral Minimal Model method estimates mean insulin sensitivity based on blood glucose and insulin levels from two mixed meal tests after exercise session

Time frame: about 12 and 24 hours after exercise

beta-cell function index

Oral Minimal Model method estimates mean beta-cell function based on blood glucose, insulin and c-peptide levels from two mixed meal tests after exercise session

Time frame: about 12 and 24 hours after exercise

total peripheral resistance

total peripheral resistance derived from BP waveform measured by finger plethysmography

Time frame: 24-hour test period after exercise

autonomic nervous system activity

derived by time-domain heart rate variability analysis

Time frame: 24-hour test period after exercise

Central Contacts

Jingyi Qian, PhD

CONTACT

6175257423 jqian@bwh.harvard.edu

Vy Nguyen, B.S.

CONTACT

617-525-0662 vnguyen42@bwh.harvard.edu

Data from ClinicalTrials.gov

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