Type 2 diabetes (T2D) confers a high risk of cardiovascular disease (CVD), particularly among older adults who tend to be physically inactive. Prolonged sedentary behavior (SB) has been shown to negatively influence markers of cardiovascular risk (e.g., blood glucose, blood pressure), even among individuals who are physically active. Most studies that have examined the effects of breaking up SB have focused on young healthy males and prioritized glycemic outcomes. Additionally, sex differences in these outcomes have not been adequately examined. The present study will address these gaps. This 3-arm crossover randomized controlled trial will compare the effects of 3 SB conditions on markers of vascular function. The 3 conditions are: 1) 4 hours of prolonged SB, 2) 4 hours of SB broken up by 5 minutes of self-paced walking every hour, and 3) 4 hours of SB with one 20-minute bout of self-paced walking. In addition to examining the overall effects of each condition, sex differences in physiological responses will be evaluated.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
34
4 hours of prolonged SB
4 hours of SB broken up by 5 minutes of self-paced walking every hour
4 hours of SB with one 20-minute bout of self-paced walking
University of Minnesota
Minneapolis, Minnesota, United States
iAUC of SBP
Net incremental area under the curve (iAUC) of systolic blood pressure (SBP)
Time frame: 90 days
Net iAUC of DBP
Net iAUC of diastolic blood pressure
Time frame: 90 days
Net iAUC of of MAP
Net iAUC of mean arterial pressure
Time frame: 90 days
Net iAUC of HR
Net iAUC of heart rate
Time frame: 90 days
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