Coronary artery disease (CAD) is the leading cause of death in end-stage renal disease (ESRD) patients requiring dialysis. There are limited data on clinical characteristics, treatment strategies and outcomes in this special patient population in China. As a nationwide, observational, multicenter cohort study, this study consecutively included ESRD patients on dialysis with significant CAD at 30 tertiary care centers in 12 provinces in China from January 2015 to June 2021. Patient data collected included demographics, comorbidities, cardiac history, cardiac function, location and severity of CAD, procedural information, medications, and clinical events.
Study Type
OBSERVATIONAL
Enrollment
1,249
China-Japan Friendship Hospital
Beijing, Beijing Municipality, China
All-cause death
All-cause deaths include cardiovascular death and non-cardiovascular death. Cardiovascular death is defined as death due to acute myocardial infarction, heart failure, sudden cardiac death, stroke, cardiovascular procedure, or cardiovascular hemorrhage. Non-cardiovascular death: any death not covered by the above definitions, such as death caused by infection, malignancy, sepsis, pulmonary causes, accident, suicide, or trauma.
Time frame: 12-month follow-up
Major adverse cardiovascular events
A composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke.
Time frame: From the hospital admission to 12-month follow-up
Major or clinically relevant nonmajor bleeding
A bleeding event meeting Bleeding Academic Research Consortium criteria type 2, 3, or 5.
Time frame: From the hospital admission to 12-month follow-up
Cardiovascular death
Cardiovascular death is defined as death due to acute myocardial infarction, heart failure, sudden cardiac death, stroke, cardiovascular procedure, or cardiovascular hemorrhage.
Time frame: From the hospital admission to 12-month follow-up
Non-fatal myocardial infarction
Non-fatal myocardial infarction is confirmed in patients with ischemic symptoms, elevated serum cardiac biomarkers and/or distinctive ECG changes.
Time frame: From the hospital admission to 12-month follow-up
Non-fatal myocardial stroke
Non-fatal myocardial stroke is confirmed as a new neurological deficit attributed to a vascular cause in the central nervous system with imaging evidence by computed tomography or magnetic resonance imaging.
Time frame: From the hospital admission to 12-month follow-up
Major bleeding
A bleeding event meeting Bleeding Academic Research Consortium criteria type 3, or 5.
Time frame: From the hospital admission to 12-month follow-up
Clinically relevant nonmajor bleeding
A bleeding event meeting Bleeding Academic Research Consortium criteria type 2.
Time frame: From the hospital admission to 12-month follow-up
Follow-up major adverse cardiovascular and clinical events
We will follow up the patients by telephone and outpatient service to know the all-cause mortality (cardiovascular and non-cardiovascular) and cardiovascular events.
Time frame: From the hospital admission, and up to 10 years
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