Comparative, Multicenter Study in Subjects with Rheumatoid Arthritis, ALVOFLEX

Inclusion Criteria: * Subjects diagnosed with active RA according to ACR/EULAR 2010 classification criteria * Subjects diagnosed with moderately to severe active RA as defined by ≥ 6 swollen (out of 66) and ≥6 tender (out of 68) joint counts, CRP \>1mg/l and with at least one of positive rheumatoid factor, positive anti-citrullinated peptide antibodies and/or evidence of 1 joint erosion of hands, wrist of dominant hand or feet at screening * Subjects must have taken methotrexate for ≥12 weeks Exclusion Criteria: * Prior treatment with biologics or Janus kinase inhibitors that may be used as disease-modifying anti-rheumatic drugs * Any past or concurrent medical conditions that could potentially increase the subject's risks or that would interfere with the study evaluation, procedures or study completion * Major chronic inflammatory disease or connective tissue disease other than RA or any active autoimmune disease * Presence of chronic obstructive pulmonary disease * Presence of chronic heart failure NYHA class III or IV