The aim of the study was to compare the profiles of vitamin C serum concentration in healthy volunteers after the single oral administration either in a liposomal or traditional formulation.
The randomized, double-blind, cross-over study was conducted under the supervision of physician on a group of 10 healthy subjects. The volunteers received 1g of vitamin C in a traditional formulation (powder in capsules), and after 14 days of a washout period 1 gram of liposomal formulation (powder in capsules). Venous blood was collected from each participant of the study immediately before the administration of a studied substance and 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 10 hours, 24 hours post the administration.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
10
1000 mg of ascorbic acid in liposomal formulation
1000 mg of ascorbic acid in traditional formulation
Medical University of Warsaw
Warsaw, Poland
Total amount of ascorbic acid that has been absorbed, defined as AUC
Comparison of the bioavailability of formulations based on the total amount of ascorbic acid that has been absorbed, defined as AUC (area under the curve)
Time frame: baseline, 30 minutes, 1, 2, 3, 4, 6, 8, 10, 24 hours post the administration
Maximum concentration of ascorbic acid (Cmax)
Maximum concentration of ascorbic acid achieved in the blood after administration of both formulations
Time frame: baseline, 30 minutes, 1, 2, 3, 4, 6, 8, 10, 24 hours post the administration
Concentration of ascorbic acid after 24 hours (C24h)
Comparison of the concentration achieved in the blood after 24 hours (C24h) from the administration of both formulations
Time frame: 24 hours post the administration
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.