The main objective of this study is to determine the mass balance, routes of elimination, and pharmacokinetics of \[14C\]-BGB-11417 in healthy male participants along with determining the concentrations of radioactivity in plasma, fecal and urinary elimination of total radioactivity.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
6
A single oral dose of liquid formulation
Ppd Development, Lp
Austin, Texas, United States
Area under the concentration curve (AUC) from time 0 to the last quantifiable concentration (AUC0-t) of BGB-11417
Time frame: From 0 to 168 hours after study drug administration
Maximum concentration (Cmax) of BGB-11417 in Plasma
Time frame: From 0 to 168 hours after study drug administration
Time to Cmax (Tmax) of BGB-11417 in Plasma
Time frame: From 0 to 168 hours after study drug administration
Amount of BGB-11417-106 excreted (Ae) and Cumulative amount of BGB-11417-106 (Cum Ae) excreted in urine and feces
Time frame: From 0 to 168 hours after study drug administration
Percentage (%Fe) and cumulative percentage (Cum %Fe) of BGB-11417 or radioactive dose excreted in urine and feces
Time frame: From 0 to 168 hours after study drug administration
Number of participants with Treatment-Emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs)
Time frame: From the day of screening until end of study (approximately 1 month)
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