Treatment Strategies for Unruptured Intracranial Aneurysms in the Chinese Population China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA)

Beijing Tiantan Hospital31,595 enrolled

Overview

The goal of this prospective observational cohort study is to learn about treatment strategies for unruptured intracranial aneurysms in the Chinese population. The main questions it aims to answer are: * To establish a cohort of patients with intracranial unruptured aneurysm and explore the optimal clinical treatment strategy. * To establish clinical management path for patients with unruptured intracranial aneurysm. According to the treatment of all patients with unruptured intracranial aneurysm, they were divided into the following groups: 1. Conservative treatment group; 2. Intracranial aneurysm clipping group; 3. Coil embolization or stent-assisted coil embolization group; 4. Flow diversion group.

Study Type

OBSERVATIONAL

Enrollment

31,595

Conditions

Unruptured Intracranial Aneurysm

Interventions

observationOTHER

observation

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: A. age \> 18 years. B. at least one intracranial aneurysm needs to be treated by craniotomy, endovascular treatment or combined surgery. C. patients' consent were obtained. Exclusion Criteria: 1. Ruptured intracranial aneurysms, accompanied by subarachnoid hemorrhage or cerebral hemorrhage ; 2. Traumatic, infectious and atrial myxoma-associated intracranial aneurysms ; 3. Combined with cerebrovascular malformations; 4. Combined with brain tumors or malignant tumors in other parts ; 5. Combined with systemic connective tissue disease and systemic rheumatic disease ; 6. Due to other diseases, or poor general condition, the expected survival time is not more than 12 months ; 7. During pregnancy and perinatal period.

Outcomes

Primary Outcomes

Primary Outcome

Functional outcomes(modified Rankin Scale,mRS) at 2 years after treatment decision

Time frame: 2 years

Secondary Outcomes

MACCE events

Incidence of major adverse cardiovascular/cerebrovascular events (MACCE events) in patients with atherosclerotic heart disease within 1 year after treatment decision.

Time frame: 1 years

cardiovascular/cerebrovascular events

Incidence of cardiovascular/cerebrovascular events in 2 years after receiving different treatment strategies.

Time frame: 2 years

Cost

Costs associated with unruptured intracranial aneurysms within 2 years after treatment with different strategies.

Time frame: 2 years

Aneurysm-related bleeding events

Incidence of aneurysmal-related bleeding events within 2 years after receiving different treatment strategies.

Time frame: 2 years

Mortality associated with intracranial aneurysms

Mortality associated with intracranial aneurysms within 2 years after treatment with different strategies

Time frame: 2 years

All-cause mortality

All-cause mortality of patients within 2 years after different treatment strategies.

Time frame: 2 years

Treatment Strategies for Unruptured Intracranial Aneurysms in the Chinese Population China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA)

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes