Abnormal high expression of fibroblast activating protein (FAP) has been found in inflammatory reactions and benign fibrosis tissue. Autoimmune nephropathy such as lupus nephritis (LN) can lead to tubular atrophy and excessive deposition of extracellular matrix, which may be accompanied by abnormally increased expression of activated FAP in kidney tissue, and lead to renal fibrosis and long-term renal failure. This makes 68Ga-labeled FAP inhibitor (FAPI) positron emission tomography (PET) imaging the potential to early assess disease severity, predict disease progress and aid treatment planning in patients with LN. Compared to renal pathological puncture, 68Ga-FAPI PET is a new tool for non-invasive, repeatable assessment of renal fibrotic activation.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
30
Activation of renal fibroblast is quantified using 68Ga-FAPI-04 PET in patients with LN.
Ruijin Hospital
Shanghai, China
RECRUITINGRenal FAP expression level
Quantitative assessment of renal fibroblast activation on FAPI PET image
Time frame: Baseline
Renal FAP expression level
Quantitative assessment of renal fibroblast activation on FAPI PET image
Time frame: 6 months after baseline
Renal FAP expression level
Quantitative assessment of renal fibroblast activation on FAPI PET image
Time frame: 12 months after baseline
Renal FAP expression level
Quantitative assessment of renal fibroblast activation on FAPI PET image
Time frame: 24 months after baseline
Renal fibrosis score
It's an immunohistochemical staining-based score after renal puncture. Higher score means a worse outcome.
Time frame: Baseline
Chronic activity score
It's an immunohistochemical staining-based scores after renal puncture. Higher score means a worse outcome.
Time frame: Baseline
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