Drug-Coated Balloon vs. Drug-Eluting Stent for Clinical Outcomes in Patients With Large Coronary Artery Disease

Inclusion Criteria: * Patient-related: 1. Patient must be ≥ 18 years of age 2. Patient is able to verbally confirm understanding of the study aim, risks, benefits, and treatment alternatives of receiving DCB or DES and he/she or his/her legally authorized representative provides written informed consent prior to any study-related procedure 3. (i) Clinical evidence of angina, and/or (ii) an abnormal functional study demonstrating myocardial ischemia due to the target lesion(s), or (iii) acute coronary syndrome \[unstable angina or non-ST-elevation myocardial infarction (NSTEMI) or uneventful STEMI (≥ 48 hours after primary PCI and no sign of thrombus in lesion(s) to treat)\] 4. Patient with lesions suitable for PCI with a DCB (and/or DES) according to the Instructions for Use 5. Patient is able to comply with the study protocol and agrees to undergo the clinical follow-up of 30 days, 6 months, 12 months, 24 months, and 36 months * Lesion-related: 1. Presence of significant de novo large vessel coronary artery disease (reference vessel diameter ≥3.0 mm by visual estimation) with either ≥ 70% diameter stenosis or intermediate ≥ 50% to \<70% diameter stenosis with abnormal functional test or symptom of ischemia 2. Successful lesion preparation. For randomisation, the lesion must satisfy the following criteria after optimal balloon angioplasty: no flow-limiting dissection (TIMI=3), and residual stenosis is ≤ 30% * Multivessel disease with two or more vessels showing diameter stenosis of 50% or more is not an exclusion as long as it fulfills all study's eligibility criteria. * In diffuse lesion, inclusion is possible if the proximal reference vessel diameter is 3.0 mm or more. Exclusion Criteria: * Patient-related: 1. Intolerance or allergy to Paclitaxel and/or the delivery matrix (main ingredient: Iopromide) 2. Severe allergy to contrast media 3. Recent STEMI (ongoing or \< 48 hours after primary PCI and/or has sign of thrombus in lesion(s) to treat) 4. NSTEMI hemodynamically unstable 5. Known left ventricular ejection fraction of \<30% 6. Inability to take dual antiplatelet therapy or anticoagulation, or single antiplatelet therapy for at least six months 7. Non-cardiac co-morbid conditions that may result in protocol non-compliance and inability of patient to complete the study (per the site investigator's medical judgment) 8. Patient with concomitant medical illnesses that require cytostatic, radiation therapy or renal replacement therapy 9. Patient who is currently/ planning to participate in another clinical trial when such participation could confound the treatment or outcomes of this study, except for observational registry 10. Pregnancy or lactation 11. Patient under administrative or judicial custody * Lesion-related: 1. Small vessel disease, defined as \<3.0 mm of reference vessel diameter by visual estimation 2. In-stent restenosis lesions for study lesions 3. Patient will be excluded if meet any of the following angiographic exclusion criteria after lesion preparation: (i) Flow limiting dissection with TIMI flow \< III (ii) Residual diameter stenosis \>30% \* The case of persistent ischemic symptoms/signs is up to the operator's decision 4. Lesions which are untreatable with PCI or other interventional techniques and coronary artery spasm in the absence of a significant stenosis 5. Left main disease or aorta-ostial lesion requiring revascularization 6. Severely calcified or tortuous vessels precluding DCB or DES application 7. Prior Coronary Artery Bypass Graft (CABG)