In the course of a scientific accompanying program, the project pursues the goal of gaining further insight into a possible connection between various influencing factors and the development of postoperative delirium. Against this background, in addition to the primary goal of exploring delirium rates, we aim to identify associations between other secondary end goals like the internal circadian time or the heart rate variability and the occurrence of postoperative delirium. For this purpose, patients of the QC-POD (NCT04355195) sample will be studied.
The project aims to improve the understanding of the internal circadian time (chronotype) and other sleep parameters, as well as further secondary end goals, in relation to the development of postoperative delirium. In the course of this the project would like to investigate the perioperative heart rate variability. Also, the association of perioperative peripheral cholinesterase activity with perioperative heart rate variability and the development of POD will be explored. Additionally, the investigator will analyze the correlation of intraoperative EEG signatures with perioperative heart rate variability, and explore any association of core body temperature and the development of postoperative Delirium.
Study Type
OBSERVATIONAL
Enrollment
100
Department of Anaesthesiology and Intensive Care Medicine, Campus Virchow-Klinikum (CVK) and Campus Charite Mitte (CCM), Charite - Universitätsmedizin Berlin
Berlin, Germany
RECRUITINGIncidence of postoperative Delirium
Incidence of postoperative delirium in all postoperative patients in normal ward, intensive care unit and recovery room with a validated delirium screening tool at two points in time.
Time frame: Up to the fifth postoperative day
Duration of Delirium
Duration (in days) of postoperative delirium in all postoperative patients in normal ward, intensive care unit and recovery room with a validated delirium screening tool at two points in time.
Time frame: The participants are followed up until the end of hospital stay, an expected average of 7 days
Bodytime
Bodytime is determined from monocytes on the morning of surgery.
Time frame: Before surgery
Chronotype 1
"Munich ChronoType Questionnaire" (MCTQ), modified for seniors is measured preoperatively and 3 months postoperatively
Time frame: Up to three months
Chronotype 2
"Morningness-Eveningness-Questionnaire" (D-MEQ) is measured preoperatively and 3 months postoperatively
Time frame: Up to three months
Heart rate variability 1
Heartrate variability 1 is measured by "ANI Monitor V2" until discharge. With the "Ani Monitor V2", heart rate variability is recorded twice a day and intraoperatively.
Time frame: The participants are followed up until the end of hospital stay, an expected average of 7 days.
Heart rate variability 2
Heartrate variability 2 is measured by "Bittium Faros 180" until discharge, except during surgery.
Time frame: The participants are followed up until the end of hospital stay, an expected average of 7 days.
Body core temperature
Body core temperature is measured with "Tcore™", a new non-invasive technology, which employs a unique dual-sensor heat flux technology.
Time frame: Up to the third postoperative day
Electroencephalography signatures
Electroencephalography signatures are measured during surgery.
Time frame: During surgery, an expected time of two hours.
Sleep monitoring 1
Sleep should be measured with a "Sleep Profiler" that generates electrooculography data.
Time frame: Up to the third postoperative day
Sleep monitoring 2
Sleep should be measured with a "Sleep Profiler" that generates electroencephalography data.
Time frame: Up to the third postoperative day
Sleep monitoring 3
Sleep should be measured with a "Sleep Profiler" that generates electromyogram data.
Time frame: Up to the third postoperative day
Insomnia Severity Index
Patients will assess their sleep quality by Insomnia Severity Index questionnaire.
Time frame: Up to three months
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