Worldwide infertility affects about 15 % of reproductive-age couples. In many cases, infertility can't be treated, new treatment options with promising value were involved in the recent clinical trials.
We will evaluate the impacts of adding coenzyme Q10 to letrozole on spermiogram and sex hormone in men diagnosed with idiopathic oligo/astheno/ teratozoospermia (iOAT) syndrome. The study will include 67 patients which will be randomly separated into two groups, Group (A) 29 patients will be treated with letrozole 2.5mg tablet orally twice a week, Group (B) 38 patient will be treated with a combination of letrozole 2.5 mg tablet orally twice a week plus Co-Q10 400mg per day, both groups complete treatment for three months. Semen sample, serum FSH, estradiol (E2), and testosterone (T) were analyzed at day one, and at the end of one, two, and three months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
74
letrozole 2.5mg twice weekly for 3 months
Coenzyme Q10 400 mg per day for 3 months
specialized center of infertility/ Nahrain University
Baghdad, Iraq
The seminal fluid analysis
sperm volume/ ml, Sperm concentration/ml, Total sperm count / ml, Progressive Sperm motility (%), Non-progressive Sperm motility (%), Immotile Sperm (%), Normal Sperm morphology (%)
Time frame: change in value from baseline to the end of 1st, 2nd and 3rd month for three consecutive months of treatment
hormone profile
concentration of Serum FSH, concentration of Serum estradiol, and concentration of Serum testosterone
Time frame: change in value from baseline to the end of 1st, 2nd and 3rd month for three consecutive months of treatment
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