Effect of Preoperative Sarcopenia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery

Second Affiliated Hospital of Nanchang University334 enrolled

Overview

The goal of this observational study is to compare Incidence of postoperative delirium in Sarcopenic and non-sarcopenic elderly patients undergoing gastrointestinal surgery. The main question it aims to answer are: • Effect of preoperative sarcopenia on postoperative delirium in elderly patients undergoing gastrointestinal surgery Participants will be evaluated preoperatively for sarcopenia and assessed for postoperative delirium, pain, etc.

Study Type

OBSERVATIONAL

Enrollment

334

Conditions

Postoperative Delirium Sarcopenia Gastrointestinal Surgery Anesthesia

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age ≥ 65 years old, gender is not limited 2. Patients to undergo elective abdominal surgery (gastrointestinal tumor resection) under general anesthesia, with an expected operation duration of about 2h\~4h 3. ASA Ⅰ-Ⅲ Exclusion Criteria: 1. Relative contraindications to general anesthesia: Patients with severe heart and lung disease, severe infection, uncontrolled hypertension, diabetes, and severe diabetic complications 2. Abnormal renal and liver function: AST or ALT≥2.5×ULN, TBIL≥1.5×ULN, Serum creatinine concentration (SCC)≥1.5×ULN 3. People with a history of mental illness or long-term use of psychotropic drugs (dementia, schizophrenia), chronic analgesic drug use, alcoholism, and cognitive impairment 4. Any cardiovascular or cerebrovascular accidents occurred within 3 months, such as myocardial infarction, stroke, transient ischemic attack 5. Myasthenia gravis patients 6. Unable to cooperate to complete the test, the patient or family member rejected the participant

Outcomes

Primary Outcomes

Incidence of postoperative delirium

Postoperative delirium was assessed using the 3D-CAM scale. It consists of 4 features, and a positive feature 1 and 2 plus 3 or 4 is considered postoperative delirium.

Time frame: Within 7 days after surgery. Delirium at any time during the 7 days after surgery was considered postoperative delirium.

Secondary Outcomes

Systolic pressure

"just entering the operating room", "immediately after intubation", "every 5 minutes after intubation until the patient leaves the operating room".

Time frame: Up to 5 hours in the operating room

Diastolic pressure

"just entering the operating room", "immediately after intubation", "every 5 minutes after intubation until the patient leaves the operating room".

Time frame: Up to 5 hours in the operating room

Mean pressure

"just entering the operating room", "immediately after intubation", "every 5 minutes after intubation until the patient leaves the operating room".

Time frame: Up to 5 hours in the operating room

Heart rate

"just entering the operating room", "immediately after intubation", "every 5 minutes after intubation until the patient leaves the operating room".

Time frame: Up to 5 hours in the operating room

Incidence of postoperative admission to ICU

Including immediate postoperative admission to ICU and postoperative admission to ICU in the ward.

Time frame: Up to 1 month after surgery

Length of stay in ICU

Duration of stay in ICU after surgery

Time frame: Up to 1 month after surgery

Postoperative pain

The degree of postoperative pain was assessed using the Numerical Rating Scale (NRS). The pain level increased sequentially from 0-10

Time frame: Within 7 days after surgery

Maximum postoperative C-reactive protein (CRP)

Only the highest CRP values detected in the normal course of gastrointestinal surgery are collected, and no additional blood sampling or interventions are performed

Time frame: Up to 1 month after surgery

Minimum postoperative albumin

Only the lowest albumin values detected in the normal course of gastrointestinal surgery are collected, and no additional blood sampling or interventions are performed

Time frame: Up to 1 month after surgery

Length of hospitalization

The total number of days the patient spent at the hospital for the current consultation

Time frame: After the patient is discharged from the hospital, average 1 month

Complication

All the perioperative complications are recorded

Time frame: During the perioperative period, up to 1 month after surgery

Effect of Preoperative Sarcopenia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts