To investigate the role of preoperative serum FGF19 level in the prognosis of biliary atresia.
Kasai portoenterostomy is currently one of the main treatment methods for biliary atresia, but about 30% of children still require liver transplantation even after receiving the surgery. Accurate prognosis will help select the most suitable treatment method for children, but there is currently a lack of effective preoperative predictive indicators. Serum FGF19 has recently been considered a possible preoperative predictive indicator for biliary atresia, but its predictive value has not been confirmed in a large sample and in Asian population, thus the investigators try to further explore the prognostic value of serum FGF19 in children with biliary atresia based on a large sample.
Study Type
OBSERVATIONAL
Enrollment
200
Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, China
RECRUITINGSerum total bilirubin level (umol/l)
The difference of serum total bilirubin level will be measured with ELISA( Enzyme Linked ImmunoSorbent Assay) three months after surgery
Time frame: Three months after surgery
Native liver survival (%)
The difference of native liver survival will be measured according to the follow-up statue one year after surgery
Time frame: One year after surgery
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