This randomized, parallel controlled, single blind trial is designed to evaluate the efficacy and safety of hydromorphone versus morphine for perioperative analgesia in lung tumor ablation.
Although the consensus of relevant guidelines and clinical studies recommend the use of opioids for perioperative analgesia in pulmonary tumor ablation surgery, there is a lack of specific analgesic programs for clinical reference. In view of the advantages of clinical application of hydromorphone and the lack of evidence for its application in perioperative analgesia of pulmonary tumor ablation, this study aims to explore the efficacy and safety of hydromorphone in perioperative analgesia of pulmonary tumor ablation, and provide some reference and suggestions for perioperative analgesia of pulmonary tumor ablation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
88
Drug: Hydromorphone Hydrochloride Hydromorphone hydrochloride injection is used for perioperative lung tumor ablation
Drug: Morphine Hydrochloride Morphine hydrochloride injection is used for perioperative lung tumor ablation
Analgesic efficiency
effective cases / total cases \* 100%. The NRS(Numeric Rating Scale) score ≤3 at all evaluation time points is considered as effective analgesia.
Time frame: The analgesia is evaluated at 1 hour before surgery, 5 minutes after the beginning of ablation
Incidence of adverse reactions
cases of adverse reactions / total cases \* 100%
Time frame: perioperative period
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