The prevalence of myopia and severe myopia are increasing and will affect 50% and 10% of the population respectively. Severe myopia exposes an increased risk of glaucoma, cataract, retinal detachment and myopic maculopathy, a source of visual impairment. To date, no European cohort study has been conducted to estimate the rate of these complications and to study the predictive parameters.
This study allows to describe the evolution of different ophthalmological parameters of a population of strong myopes during their follow-up for 10 years using multimodal imaging techniques of the retina. Prospective, longitudinal, multicentric, non-randomized cohort study with constitution of a biological collection. This study will include major and minor patients with high myopia
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
1,000
The additioan acts in this research are: Fonctionnal phenotyping:Retinal sensitivity and fixation stability assessment using microperimetry, assessment of long-term fixation stability Structural Phenotyping: Anterior segment examination with OCT anterior Blood sample collection
Visual acuity
Using the ETDRS and the near vision scale (decimal scales converted to logMAR)
Time frame: 10 years
Refraction measures
Measure will be performed in diopter
Time frame: 10 years
Lens opacity
Measure will be performed in pixel units
Time frame: 10 years
Intraocular pressure and pachymetry
These measurements are respectively carried out in mmHg and in μm
Time frame: 10 years
Retinal sensitivity and fixation stability
Respectively Performed in decibels and by microperimetry
Time frame: 10 years
Central visual field deficits
by automatic perimetry in decibels
Time frame: 10 years
Axial length
Will be performed in mm
Time frame: 10 years
Quantitative data
On optical coherence tomography (OCT) and OCT-Angiography
Time frame: 10 years
qualitative data on OCT :
presence of any macular complications: * condition of the posterior vitreous * presence of inner or outer retinal alteration (fluid, layer disorganization, band interruption...).
Time frame: 10 years
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Area of Rétinal atrophy
In autofluorescence (in mm²)
Time frame: 10 years
Characterization of the type of staphyloma
staphyloma classification
Time frame: 10 years
Vitreous status
Liquefaction, stage of posterior vitreous detachment
Time frame: 10 years
Excavation of the optic nerve and area
In mm² of peripapillary atrophy on color and autofluorescence images
Time frame: 10 years
Anterior segment status
Chamber measurement, corneal curvature (in mm)
Time frame: 10 years
Macular ophthalmologic complications
Diffuse atrophy/patch atrophy/macular atrophy * Choroidal neovessel * Bruch's membrane rupture * Bulging macula * Papillary dysversion * Myopic staphyloma * Epiretinal membrane * Lamellar hole * Myopic foveoschisis * Macular hole
Time frame: 10 years
Non-macular ophthalmologic complications
* Glaucoma optic Neuropathy * Cataract * Retinal detachment
Time frame: 10 years